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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
31
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pubmed:dateCreated |
2008-10-31
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pubmed:abstractText |
We recently reported DNA methylation of the paired-like homeodomain transcription factor 2 (PITX2) gene to be strongly correlated with increased risk of recurrence in node-negative, hormone receptor-positive, tamoxifen-treated breast cancer patients using fresh frozen specimens. Aims of the present study were to establish determination of PITX2 methylation for routine analysis in formalin-fixed paraffin-embedded (FFPE) breast cancer tissue and to test PITX2 DNA methylation as a biomarker for outcome prediction in an independent patient cohort.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1527-7755
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pubmed:author |
pubmed-author:CuferTanjaT,
pubmed-author:FoekensJohnJ,
pubmed-author:GrützmannRobertR,
pubmed-author:HarbeckNadiaN,
pubmed-author:HartmannArndtA,
pubmed-author:HartmannOliverO,
pubmed-author:KristiansenGlenG,
pubmed-author:LescheRalfR,
pubmed-author:LukasAntjeA,
pubmed-author:MüllerVolkmarV,
pubmed-author:MaierSabineS,
pubmed-author:MargossianAstridA,
pubmed-author:MartensJohnJ,
pubmed-author:Milde-LangoschKarinK,
pubmed-author:NährigJörgJ,
pubmed-author:NimmrichInkoI,
pubmed-author:ParadisoAngeloA,
pubmed-author:RossJeffrey SJS,
pubmed-author:SchmittManfredM,
pubmed-author:SchwopeInaI
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5036-42
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pubmed:meshHeading |
pubmed-meshheading:18711169-Adult,
pubmed-meshheading:18711169-Aged,
pubmed-meshheading:18711169-Aged, 80 and over,
pubmed-meshheading:18711169-Argentina,
pubmed-meshheading:18711169-Breast Neoplasms,
pubmed-meshheading:18711169-DNA Methylation,
pubmed-meshheading:18711169-Europe,
pubmed-meshheading:18711169-Female,
pubmed-meshheading:18711169-Frozen Sections,
pubmed-meshheading:18711169-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18711169-Homeodomain Proteins,
pubmed-meshheading:18711169-Humans,
pubmed-meshheading:18711169-Lymph Nodes,
pubmed-meshheading:18711169-Middle Aged,
pubmed-meshheading:18711169-Neoplasm Metastasis,
pubmed-meshheading:18711169-New York,
pubmed-meshheading:18711169-Paraffin Embedding,
pubmed-meshheading:18711169-Polymerase Chain Reaction,
pubmed-meshheading:18711169-Predictive Value of Tests,
pubmed-meshheading:18711169-Reproducibility of Results,
pubmed-meshheading:18711169-Selective Estrogen Receptor Modulators,
pubmed-meshheading:18711169-Tamoxifen,
pubmed-meshheading:18711169-Time Factors,
pubmed-meshheading:18711169-Transcription Factors,
pubmed-meshheading:18711169-Treatment Outcome,
pubmed-meshheading:18711169-Tumor Markers, Biological
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pubmed:year |
2008
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pubmed:articleTitle |
Multicenter study using paraffin-embedded tumor tissue testing PITX2 DNA methylation as a marker for outcome prediction in tamoxifen-treated, node-negative breast cancer patients.
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pubmed:affiliation |
Department of Obstetrics and Gynecology and Pathology, Technical University of Munich, Munich, Germany. nadia.harbeck@lrz.tu-muenchen.de
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Validation Studies
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