Source:http://linkedlifedata.com/resource/pubmed/id/18710022
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2008-8-19
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| pubmed:abstractText |
Expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB-3) mRNA alternative splice variants was studied in different mouse tissues in hypoxic conditions in vivo. Significant increase of the expression of PFKFB-3 mRNA was observed in the mouse lungs, testes and brain in hypoxia. Several new alternative splice variants of PFKFB-3 mRNA were identified in the lung, testis, brain and skeletal muscle. They have different length and amino acid sequence of C-terminal regulatory part. However, 6-phosphofructo-2-kinase and fructose-2,6-bisphosphatase catalytic domains were identical. Moreover, the expression of different alternative splice variants of PFKFB-3 mRNA has shown tissue specificity and different levels of induction in hypoxic conditions in vivo. Results of this investigation indicate a possible role of PFKFB-3 splice isoform in cell adaptation to hypoxic conditions.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0201-8470
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
80
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
19-25
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| pubmed:meshHeading |
pubmed-meshheading:18710022-Adaptation, Physiological,
pubmed-meshheading:18710022-Alternative Splicing,
pubmed-meshheading:18710022-Amino Acid Sequence,
pubmed-meshheading:18710022-Animals,
pubmed-meshheading:18710022-Anoxia,
pubmed-meshheading:18710022-Brain,
pubmed-meshheading:18710022-Gene Expression,
pubmed-meshheading:18710022-Isoenzymes,
pubmed-meshheading:18710022-Lung,
pubmed-meshheading:18710022-Male,
pubmed-meshheading:18710022-Mice,
pubmed-meshheading:18710022-Mice, Inbred C57BL,
pubmed-meshheading:18710022-Molecular Sequence Data,
pubmed-meshheading:18710022-Muscle, Skeletal,
pubmed-meshheading:18710022-Phosphofructokinase-2,
pubmed-meshheading:18710022-RNA, Messenger,
pubmed-meshheading:18710022-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18710022-Testis
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| pubmed:articleTitle |
Expression of mouse 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 mRNA alternative splice variants in hypoxia.
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| pubmed:affiliation |
Palladin Institute of Biochemistry, National Academy of Science of Ukraine, Kyiv, Ukraine.
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| pubmed:publicationType |
Journal Article
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