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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21-22
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pubmed:dateCreated |
2008-9-15
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pubmed:abstractText |
Here we show that in contrast to other cancer types, tumor necrosis factor (TNF)-alpha suppresses YKL-40 expression in glioma cell lines in a nuclear factor kappaB (NF-kappaB) dependent manner. Even though TNF-alpha causes recruitment of p65 and p50 subunits of NF-kappaB to the YKL-40 promoter in all cell types, recruitment of histone deacetylases (HDAC)-1 and -2, and a consequent deacetylation of histone H3 at the YKL-40 promoter occurs only in glioma cells. Importantly, using chromatin immunoprecipitation assays in frozen glioblastoma multiforme tissues, we show that YKL-40 levels decrease consistent with HDAC1 recruitment despite high levels of nuclear p-p65. This study presents a paradigm for NF-kappaB regulation of one of its targets in a strict cell type specific manner.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adipokines,
http://linkedlifedata.com/resource/pubmed/chemical/CHI3L1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/HDAC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylases,
http://linkedlifedata.com/resource/pubmed/chemical/Histones,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B p50 Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor RelA,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
582
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3193-200
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18708058-Acetylation,
pubmed-meshheading:18708058-Adipokines,
pubmed-meshheading:18708058-Cell Line, Tumor,
pubmed-meshheading:18708058-Chromatin Immunoprecipitation,
pubmed-meshheading:18708058-Down-Regulation,
pubmed-meshheading:18708058-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18708058-Glioma,
pubmed-meshheading:18708058-Glycoproteins,
pubmed-meshheading:18708058-Histone Deacetylase 1,
pubmed-meshheading:18708058-Histone Deacetylase 2,
pubmed-meshheading:18708058-Histone Deacetylases,
pubmed-meshheading:18708058-Histones,
pubmed-meshheading:18708058-Humans,
pubmed-meshheading:18708058-Lectins,
pubmed-meshheading:18708058-NF-kappa B,
pubmed-meshheading:18708058-NF-kappa B p50 Subunit,
pubmed-meshheading:18708058-Promoter Regions, Genetic,
pubmed-meshheading:18708058-Repressor Proteins,
pubmed-meshheading:18708058-Transcription Factor RelA,
pubmed-meshheading:18708058-Tumor Necrosis Factor-alpha
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pubmed:year |
2008
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pubmed:articleTitle |
Selective repression of YKL-40 by NF-kappaB in glioma cell lines involves recruitment of histone deacetylase-1 and -2.
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pubmed:affiliation |
Brain Tumor Center, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. kbhat@mdanderson.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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