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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-4-21
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pubmed:abstractText |
L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) remains a challenge in Parkinson's disease (PD) drug therapy. In the present study, we examined the effect of L-stepholidine (L-SPD), a known dual dopamine receptor agent, on LID in 6-hydroxydopamine (6-OHDA)-lesioned PD rat model. Daily administration of L-DOPA to PD rats for 22 days induced steady expression of LID, co-administration of L-SPD with L-DOPA significantly ameliorated LID without compromising the therapeutic potency of L-DOPA, indicating that L-SPD attenuated LID development. L-SPD alone elicited stable contralateral rotational behavior without inducing significant dyskinesia. Acute administration of L-SPD to rats with established LID produced significant relief of dyskinesia; this effect was mimicked by D(2) receptor antagonist haloperidol, but blunted by 5-HT(1A) receptor antagonist WAY100635. Furthermore, the mRNA level of 5-HT(1A) decreased significantly on 6-OHDA-lesioned striata, whereas chronic L-SPD treatment restored 5-HT(1A) receptor mRNA level on the lesioned striata. The present data demonstrated that L-SPD elicited antidyskinesia effects via both dopamine (D(2) receptor antagonistic activity) and nondopamine (5-HT(1A) agonistic activity) mechanisms.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-Hydroxy-2-(di-n-propylamino)tetral...,
http://linkedlifedata.com/resource/pubmed/chemical/Antiparkinson Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antipsychotic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Benzazepines,
http://linkedlifedata.com/resource/pubmed/chemical/Berberine,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Levodopa,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidopamine,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT1A,
http://linkedlifedata.com/resource/pubmed/chemical/SCH 23390,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Tritium,
http://linkedlifedata.com/resource/pubmed/chemical/stepholidine
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1558-1497
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2008 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
926-36
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18707801-8-Hydroxy-2-(di-n-propylamino)tetralin,
pubmed-meshheading:18707801-Analysis of Variance,
pubmed-meshheading:18707801-Animals,
pubmed-meshheading:18707801-Antiparkinson Agents,
pubmed-meshheading:18707801-Antipsychotic Agents,
pubmed-meshheading:18707801-Benzazepines,
pubmed-meshheading:18707801-Berberine,
pubmed-meshheading:18707801-CHO Cells,
pubmed-meshheading:18707801-Corpus Striatum,
pubmed-meshheading:18707801-Cricetinae,
pubmed-meshheading:18707801-Cricetulus,
pubmed-meshheading:18707801-Disease Models, Animal,
pubmed-meshheading:18707801-Dopamine Agents,
pubmed-meshheading:18707801-Drug Administration Schedule,
pubmed-meshheading:18707801-Drug Interactions,
pubmed-meshheading:18707801-Dyskinesias,
pubmed-meshheading:18707801-Gene Expression Regulation,
pubmed-meshheading:18707801-Levodopa,
pubmed-meshheading:18707801-Male,
pubmed-meshheading:18707801-Oxidopamine,
pubmed-meshheading:18707801-Parkinsonian Disorders,
pubmed-meshheading:18707801-RNA, Messenger,
pubmed-meshheading:18707801-Rats,
pubmed-meshheading:18707801-Rats, Sprague-Dawley,
pubmed-meshheading:18707801-Receptor, Serotonin, 5-HT1A,
pubmed-meshheading:18707801-Serotonin Receptor Agonists,
pubmed-meshheading:18707801-Transfection,
pubmed-meshheading:18707801-Tritium
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pubmed:year |
2010
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pubmed:articleTitle |
L-stepholidine reduced L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease.
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pubmed:affiliation |
State Key Laboratory of Drug Research, Department of Neuropharmacology, Shanghai Institute of Material Medica, Chinese Academy of Sciences, Shanghai, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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