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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-9-15
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pubmed:abstractText |
Osteosarcoma cell lines and tumors have been shown to express epidermal growth factor receptor (EGFR) and harbor amplifications at the EGFR locus. In this study, the authors further analyzed the genomic features of EGFR in osteosarcoma tumors and investigated whether they correlate with phosphatase and tensin homolog (PTEN) expression and copy number status.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2008 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
113
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1453-61
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18704985-Adolescent,
pubmed-meshheading:18704985-Adult,
pubmed-meshheading:18704985-Bone Neoplasms,
pubmed-meshheading:18704985-Child,
pubmed-meshheading:18704985-Child, Preschool,
pubmed-meshheading:18704985-Female,
pubmed-meshheading:18704985-Gene Amplification,
pubmed-meshheading:18704985-Gene Dosage,
pubmed-meshheading:18704985-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18704985-Humans,
pubmed-meshheading:18704985-Immunoenzyme Techniques,
pubmed-meshheading:18704985-In Situ Hybridization, Fluorescence,
pubmed-meshheading:18704985-Male,
pubmed-meshheading:18704985-Mutation,
pubmed-meshheading:18704985-Osteosarcoma,
pubmed-meshheading:18704985-PTEN Phosphohydrolase,
pubmed-meshheading:18704985-Polymorphism, Single Nucleotide,
pubmed-meshheading:18704985-Prognosis,
pubmed-meshheading:18704985-Receptor, Epidermal Growth Factor,
pubmed-meshheading:18704985-Survival Rate
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pubmed:year |
2008
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pubmed:articleTitle |
Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors.
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pubmed:affiliation |
Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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