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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0024204,
umls-concept:C0027627,
umls-concept:C0030705,
umls-concept:C0058402,
umls-concept:C0062505,
umls-concept:C0166825,
umls-concept:C0185117,
umls-concept:C0332281,
umls-concept:C0380603,
umls-concept:C1333897,
umls-concept:C1335200,
umls-concept:C1335302,
umls-concept:C1704816,
umls-concept:C1707520,
umls-concept:C2248595,
umls-concept:C2911684
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pubmed:issue |
10
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pubmed:dateCreated |
2008-9-22
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pubmed:abstractText |
Pancreatic cancer still has one of the worst prognoses of all cancers with a 5-year survival rate of 5%, making it necessary to find markers or gene sets that would further classify patients into different risk categories and thus allow more individually adapted multimodality treatment regimens. Especially heparanase (HPSE) has recently been discussed as a key factor in pancreatic cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronidase,
http://linkedlifedata.com/resource/pubmed/chemical/HIF1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet-Derived Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/heparanase,
http://linkedlifedata.com/resource/pubmed/chemical/heparin-binding EGF-like growth...,
http://linkedlifedata.com/resource/pubmed/chemical/platelet-derived growth factor A
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1873-4626
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pubmed:author |
pubmed-author:AzumaMizutomoM,
pubmed-author:BaldusStephan ESE,
pubmed-author:BrabenderJanJ,
pubmed-author:DanenbergKathleen DKD,
pubmed-author:DanenbergPeter VPV,
pubmed-author:DrebberUtaU,
pubmed-author:HoelscherArnulf HAH,
pubmed-author:HoffmannAndreas-ClaudiusAC,
pubmed-author:HoffmannChristinaC,
pubmed-author:KleinEllenE,
pubmed-author:MetzgerRalfR,
pubmed-author:MoriRyutaroR,
pubmed-author:PrenzelKlaus LKL,
pubmed-author:VallbohmerDanielD
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pubmed:issnType |
Electronic
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1674-81; discussion 1681-2
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pubmed:meshHeading |
pubmed-meshheading:18704599-Adult,
pubmed-meshheading:18704599-Aged,
pubmed-meshheading:18704599-Aged, 80 and over,
pubmed-meshheading:18704599-Carcinoma, Pancreatic Ductal,
pubmed-meshheading:18704599-Cell Differentiation,
pubmed-meshheading:18704599-Female,
pubmed-meshheading:18704599-Fibroblast Growth Factor 2,
pubmed-meshheading:18704599-Gene Expression,
pubmed-meshheading:18704599-Glucuronidase,
pubmed-meshheading:18704599-Humans,
pubmed-meshheading:18704599-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:18704599-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:18704599-Lymph Nodes,
pubmed-meshheading:18704599-Lymphatic Metastasis,
pubmed-meshheading:18704599-Male,
pubmed-meshheading:18704599-Middle Aged,
pubmed-meshheading:18704599-Pancreatic Neoplasms,
pubmed-meshheading:18704599-Pilot Projects,
pubmed-meshheading:18704599-Platelet-Derived Growth Factor
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pubmed:year |
2008
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pubmed:articleTitle |
High expression of heparanase is significantly associated with dedifferentiation and lymph node metastasis in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA and via HIF1a to HB-EGF and bFGF.
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pubmed:affiliation |
Department of Biochemistry and Molecular Biology and Norris Comprehensive Cancer Center, University of Southern California, 1640 Marengo Street, Suite 600, Los Angeles, CA 90033, USA. ach@o117.com
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pubmed:publicationType |
Journal Article
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