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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-10-14
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pubmed:abstractText |
We investigated the changes in the expression of vascular endothelial growth factor-C (VEGF-C) and its receptor, VEGFR-3, in the rat hippocampus following transient forebrain ischemia. The expression profiles of VEGF-C and VEGFR-3 were very similar in the control hippocampi, where both genes were constitutively expressed in neurons in the pyramidal cell and granule cell layers. The spatiotemporal expression pattern of VEGF-C was similar to that of VEGFR-3 in the ischemic hippocampus, and in the CA1 and dentate hilar regions both VEGF-C and VEGFR-3 were strongly expressed in activated glial cells rather than in neurons. Most of the activated glial cells expressing both genes were reactive astrocytes, although some were a subpopulation of brain macrophages. In the dentate gyrus, however, VEGFR-3 expression was transiently increased in the innermost layer of granule cells on days 7-10 after reperfusion, coinciding with an increase in polysialylated neural cell adhesion molecule staining--a marker for immature neurons. These data suggest that VEGF-C may be involved in glial reaction via paracrine or autocrine mechanisms in the ischemic brain and may carry out specific roles in adult hippocampal neurogenesis during ischemic insults.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1432-0533
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
517-27
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18704465-Animals,
pubmed-meshheading:18704465-Astrocytes,
pubmed-meshheading:18704465-Dentate Gyrus,
pubmed-meshheading:18704465-Disease Models, Animal,
pubmed-meshheading:18704465-Fluorescent Antibody Technique,
pubmed-meshheading:18704465-Glial Fibrillary Acidic Protein,
pubmed-meshheading:18704465-Hippocampus,
pubmed-meshheading:18704465-In Situ Hybridization,
pubmed-meshheading:18704465-Ischemic Attack, Transient,
pubmed-meshheading:18704465-Male,
pubmed-meshheading:18704465-Nerve Tissue Proteins,
pubmed-meshheading:18704465-Neuroglia,
pubmed-meshheading:18704465-Neurons,
pubmed-meshheading:18704465-Prosencephalon,
pubmed-meshheading:18704465-Pyramidal Cells,
pubmed-meshheading:18704465-RNA, Messenger,
pubmed-meshheading:18704465-Rats,
pubmed-meshheading:18704465-Rats, Sprague-Dawley,
pubmed-meshheading:18704465-Receptors, Vascular Endothelial Growth Factor,
pubmed-meshheading:18704465-Reperfusion,
pubmed-meshheading:18704465-Up-Regulation,
pubmed-meshheading:18704465-Vascular Endothelial Growth Factor C,
pubmed-meshheading:18704465-Vascular Endothelial Growth Factor Receptor-3
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pubmed:year |
2008
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pubmed:articleTitle |
Differential regulation of vascular endothelial growth factor-C and its receptor in the rat hippocampus following transient forebrain ischemia.
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pubmed:affiliation |
Department of Anatomy, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-gu, Seoul, 137-701, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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