|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
17
|
|
pubmed:dateCreated |
2008-9-3
|
|
pubmed:abstractText |
Introns may affect gene expression by increasing the time required to transcribe the gene. One way for extended transcription times to affect the behavior of a gene expression program is through a negative feedback loop. Here, we show that a logically engineered negative feedback loop in animal cells produces expression pulses, which have a broad time distribution that increases with intron length. These results in combination with mathematical models provide insight into what may produce the intron-dependent pulse distributions. We conclude that the long production time required for large intron-containing genes is significant for the behavior of gene expression programs.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-10850721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-11181995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-11753368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-12370445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-12417193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-12424381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-12426104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-12432409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-12730602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-12932323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-12932324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-14604986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-14730303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-1522901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-16360033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-16541077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-16543458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-1680567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-16883354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-16951679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-17048983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-18331713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-5641411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-5861813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-7719347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-7891716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-8365292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18703678-9857028
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0890-9369
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
22
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2342-6
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:18703678-3T3 Cells,
pubmed-meshheading:18703678-Animals,
pubmed-meshheading:18703678-Cell Line,
pubmed-meshheading:18703678-Feedback, Physiological,
pubmed-meshheading:18703678-Gene Expression Regulation,
pubmed-meshheading:18703678-Introns,
pubmed-meshheading:18703678-Mice,
pubmed-meshheading:18703678-Models, Genetic,
pubmed-meshheading:18703678-Periodicity,
pubmed-meshheading:18703678-Transcription, Genetic
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Intron length increases oscillatory periods of gene expression in animal cells.
|
|
pubmed:affiliation |
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
