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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-4
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pubmed:dateCreated |
2008-12-9
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pubmed:abstractText |
Biglycan (BGN) and WISP-1 are 2 extracellular matrix proteins that bind to each other and colocalize in mineralizing tissue. Here we show that WISP-1 abrogates the repression of proliferation in bone marrow stromal cells induced by BGN. We also demonstrate that WISP-1 and its variant WISP-1va can alleviate the repressed osteogenic differentiation caused by the absence of BGN. These preliminary data suggest that WISP-1 and BGN may functionally interact and control each other's activity, thus regulating the differentiation and proliferation of osteogenic cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18701807-11571650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18701807-11598131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18701807-11811564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18701807-15173106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18701807-15331410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18701807-16160746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18701807-17130294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18701807-6189828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18701807-8781050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18701807-9312200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18701807-9731537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18701807-9843955
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BGN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Bgn protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Biglycan,
http://linkedlifedata.com/resource/pubmed/chemical/Bromodeoxyuridine,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/WISP1 protein, human
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pubmed:status |
MEDLINE
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pubmed:issn |
1422-6421
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2008 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
189
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
153-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18701807-Animals,
pubmed-meshheading:18701807-Biglycan,
pubmed-meshheading:18701807-Bone Marrow Cells,
pubmed-meshheading:18701807-Bromodeoxyuridine,
pubmed-meshheading:18701807-Cell Differentiation,
pubmed-meshheading:18701807-Cell Proliferation,
pubmed-meshheading:18701807-Extracellular Matrix Proteins,
pubmed-meshheading:18701807-Fluorescent Antibody Technique,
pubmed-meshheading:18701807-Humans,
pubmed-meshheading:18701807-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:18701807-Mice,
pubmed-meshheading:18701807-Microscopy, Confocal,
pubmed-meshheading:18701807-Osteocytes,
pubmed-meshheading:18701807-Protein Binding,
pubmed-meshheading:18701807-Protein Structure, Tertiary,
pubmed-meshheading:18701807-Proteoglycans,
pubmed-meshheading:18701807-Proto-Oncogene Proteins,
pubmed-meshheading:18701807-Stromal Cells
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pubmed:year |
2009
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pubmed:articleTitle |
The potential functional interaction of biglycan and WISP-1 in controlling differentiation and proliferation of osteogenic cells.
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pubmed:affiliation |
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS Bethesda, Bethesda, Md. 20892-4320, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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