Linked Life Data

18700878

Source:http://linkedlifedata.com/resource/pubmed/id/18700878

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-10-2
pubmed:abstractText
Soluble human leukocyte antigen-G (sHLA-G) functions as a multiple immunoregulator. A 14 bp insertion (+14 bp)/deletion (-14 bp) polymorphism in exon 8 of the HLA-G gene has been proposed to be associated with HLA-G mRNA stability and the expression of HLA-G. In the current study, a total of 150 normal Chinese Han population had been genotyped for the +14 bp/-14 bp polymorphism, and the expression of plasma sHLA-G was determined with enzyme-linked immunosorbent assay in these case-matched plasma. Data showed that genotype of 14 bp polymorphism was significantly associated with sHLA-G expression. Plasma sHLA-G level with the +14 bp/+14 bp genotype was dramatically lower than that with +14 bp/-14 bp (P = 0.004) and -14 bp/-14 bp genotypes (P = 0.003), while no dramatic difference was observed between the +14 bp/-14 bp and -14 bp/-14 bp genotypes (P > 0.05). In both males and females, plasma sHLA-G with the +14 bp/+14 bp genotype was also significantly lower when compared with other two respective 14 bp genotypes. Data also showed that sHLA-G expression was unrelated to gender. This study suggests that the 14 bp deletion polymorphism in the HLA-G gene plays an important role in sHLA-G expression and that interpretation of the potential biological functions of sHLA-G should be made with caution, taking the polymorphism into consideration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1399-0039
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
335-41
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The 14 bp deletion polymorphisms in HLA-G gene play an important role in the expression of soluble HLA-G in plasma.
pubmed:affiliation
Department of Laboratory Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't