| pubmed-article:18700620 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18700620 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:18700620 | lifeskim:mentions | umls-concept:C0026922 | lld:lifeskim |
| pubmed-article:18700620 | lifeskim:mentions | umls-concept:C0370231 | lld:lifeskim |
| pubmed-article:18700620 | lifeskim:mentions | umls-concept:C1819464 | lld:lifeskim |
| pubmed-article:18700620 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:18700620 | lifeskim:mentions | umls-concept:C1510438 | lld:lifeskim |
| pubmed-article:18700620 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18700620 | pubmed:dateCreated | 2008-8-14 | lld:pubmed |
| pubmed-article:18700620 | pubmed:abstractText | Phenolic glycolipid-I (PGL-I) is known to be a major antigen of Mycobacterium leprae. We have studied the influence of PGL-I on the production of Tumour Necrosis Factor alpha (TNF-alpha) using the in vitro whole blood assay. Armadillo-derived M. leprae (ADML) are thought to be depleted of PGL-I during the purification process. M. leprae obtained from mouse foot pad material (MFPML) has been subjected to a less rigorous purification process; their PGL-I coating is therefore believed to be more intact than that of ADML. PGL-I or ADML alone induced the secretion of minimal levels of TNF-alpha in whole blood assay; when added in combination, higher levels of this cytokine were observed. The highest TNF-alpha response was seen following stimulation with MFPML. MFP material not infected with ML did not elicit any response. The difference in TNF-alpha response shown by ADML and MFPML was postulated to be largely due to the presence of higher levels of PGL-I in MFPML. This increase in TNF-alpha production suggests that PGL-I may play a significant role in the induction of TNF-alpha during natural infection. | lld:pubmed |
| pubmed-article:18700620 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18700620 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18700620 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18700620 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18700620 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18700620 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18700620 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18700620 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18700620 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:18700620 | pubmed:author | pubmed-author:MacdonaldMM | lld:pubmed |
| pubmed-article:18700620 | pubmed:author | pubmed-author:DhungelSS | lld:pubmed |
| pubmed-article:18700620 | pubmed:author | pubmed-author:RanjitCC | lld:pubmed |
| pubmed-article:18700620 | pubmed:author | pubmed-author:SapkotaB RBR | lld:pubmed |
| pubmed-article:18700620 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:18700620 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18700620 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18700620 | pubmed:pagination | 1-3 | lld:pubmed |
| pubmed-article:18700620 | pubmed:meshHeading | pubmed-meshheading:18700620... | lld:pubmed |
| pubmed-article:18700620 | pubmed:meshHeading | pubmed-meshheading:18700620... | lld:pubmed |
| pubmed-article:18700620 | pubmed:meshHeading | pubmed-meshheading:18700620... | lld:pubmed |
| pubmed-article:18700620 | pubmed:meshHeading | pubmed-meshheading:18700620... | lld:pubmed |
| pubmed-article:18700620 | pubmed:meshHeading | pubmed-meshheading:18700620... | lld:pubmed |
| pubmed-article:18700620 | pubmed:meshHeading | pubmed-meshheading:18700620... | lld:pubmed |
| pubmed-article:18700620 | pubmed:meshHeading | pubmed-meshheading:18700620... | lld:pubmed |
| pubmed-article:18700620 | pubmed:meshHeading | pubmed-meshheading:18700620... | lld:pubmed |
| pubmed-article:18700620 | pubmed:meshHeading | pubmed-meshheading:18700620... | lld:pubmed |
| pubmed-article:18700620 | pubmed:meshHeading | pubmed-meshheading:18700620... | lld:pubmed |
| pubmed-article:18700620 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18700620 | pubmed:articleTitle | Role of PGL-I of M. leprae in TNF-alpha production by in vitro whole blood assay. | lld:pubmed |
| pubmed-article:18700620 | pubmed:affiliation | Leprosy Mission Nepal, Anandaban Hospital, Kathmandu, Nepal. | lld:pubmed |
| pubmed-article:18700620 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18700620 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
