Linked Life Data

18699930

Source:http://linkedlifedata.com/resource/pubmed/id/18699930

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2008-8-13
pubmed:abstractText
Micro-organisms constantly invade the human body and may form a threat to our health. Traditionally, concepts of defence mechanisms have included a protective outer layer of epithelia and a vigilant immune system searching for areas where the integrity of the outer layer may be compromised. Instead of considering these elements as two independent mechanisms, we should be treating them as a single integrated system. This review will present and discuss the role of local immune-competent cells and local epithelia in the recognition of potential pathogens and how the interaction between the two components may affect the initiation of the airway immune response. A concept emerges where airway mucosal dendritic cells act as integrators of both immunostimulatory and immunosuppressive signals that act within actively-involved mucosal tissue.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1398-9995
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1124-35
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Interactions between epithelial cells and dendritic cells in airway immune responses: lessons from allergic airway disease.
pubmed:affiliation
Department of Otorhinolaryngology, Academic Medical Centre, Amsterdam, The Neitherlands.
pubmed:publicationType
Journal Article, Review