|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0007407,
umls-concept:C0009566,
umls-concept:C0018591,
umls-concept:C0023570,
umls-concept:C0030567,
umls-concept:C0035647,
umls-concept:C0087111,
umls-concept:C0205245,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2008-8-21
|
|
pubmed:abstractText |
Differences in catechol-O-methyltransferase (COMT) activity and genotype may determine individual variations in the therapeutic response to levodopa or Parkinson's disease (PD) susceptibility. The role of functional COMT haplotypes in PD susceptibility and treatment response has not been examined.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1744-6872
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
18
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
815-21
|
|
pubmed:meshHeading |
pubmed-meshheading:18698234-Adult,
pubmed-meshheading:18698234-Age of Onset,
pubmed-meshheading:18698234-Aged,
pubmed-meshheading:18698234-Aged, 80 and over,
pubmed-meshheading:18698234-Antiparkinson Agents,
pubmed-meshheading:18698234-Case-Control Studies,
pubmed-meshheading:18698234-Catechol O-Methyltransferase,
pubmed-meshheading:18698234-Dose-Response Relationship, Drug,
pubmed-meshheading:18698234-Female,
pubmed-meshheading:18698234-Haplotypes,
pubmed-meshheading:18698234-Humans,
pubmed-meshheading:18698234-Levodopa,
pubmed-meshheading:18698234-Male,
pubmed-meshheading:18698234-Middle Aged,
pubmed-meshheading:18698234-Parkinson Disease,
pubmed-meshheading:18698234-Polymerase Chain Reaction,
pubmed-meshheading:18698234-Polymorphism, Genetic
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications.
|
|
pubmed:affiliation |
Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstancow Wikp. 72, Szczecin, Poland. monika-bialecka@post.pl
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|
pubmed:publicationType |
Journal Article,
Randomized Controlled Trial
|
