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pubmed-article:18698171pubmed:abstractTextSystemic lupus erythematosus etiology includes both genetic and environmental factors. Evidence suggests that many genetic loci in humans and mouse models contribute to the occurrence and clinical presentation of lupus. This large array of different genes affects many aspects of immune cell function, including the activation and functional differentiation of B cells, T cells, dendritic cells and other immune cells. In particular, the T-cell components that contribute to systemic lupus erythematosus pathogenesis are incompletely defined.lld:pubmed
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pubmed-article:18698171pubmed:articleTitleIL-17 and the Th17 lineage in systemic lupus erythematosus.lld:pubmed
pubmed-article:18698171pubmed:affiliationDepartment of Biochemistry, School of Medicine and Biomedical Sciences, The University at Buffalo, State University of New York, Buffalo, New York 14203, USA. leesinha@buffalo.edulld:pubmed
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