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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2008-9-12
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pubmed:abstractText |
Functional chemokine receptors are expressed in many malignant tumors, including papillary thyroid carcinoma (PTC). These receptors promote tumor growth and metastasis in response to endogenous chemokines. The purpose of this study was to examine the expression of two chemokine receptors-CXCR4 and CCR7-in a series of PTCs. We hypothesized that CXCR4 and CCR7 would correlate with indicators of tumor aggressiveness, including tumor size, extrathyroidal extension (ETE), angiolymphatic invasion (ALI), and lymph node metastasis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCR7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CXCR4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR7,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR4
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1534-4681
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2833-41
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pubmed:meshHeading |
pubmed-meshheading:18696160-Adenocarcinoma, Papillary,
pubmed-meshheading:18696160-Adult,
pubmed-meshheading:18696160-Cohort Studies,
pubmed-meshheading:18696160-Female,
pubmed-meshheading:18696160-Gene Expression Profiling,
pubmed-meshheading:18696160-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18696160-Humans,
pubmed-meshheading:18696160-Immunoenzyme Techniques,
pubmed-meshheading:18696160-Lymph Nodes,
pubmed-meshheading:18696160-Lymphatic Metastasis,
pubmed-meshheading:18696160-Male,
pubmed-meshheading:18696160-Neoplasm Invasiveness,
pubmed-meshheading:18696160-Neoplasm Staging,
pubmed-meshheading:18696160-Prognosis,
pubmed-meshheading:18696160-RNA, Messenger,
pubmed-meshheading:18696160-RNA, Neoplasm,
pubmed-meshheading:18696160-Receptors, CCR7,
pubmed-meshheading:18696160-Receptors, CXCR4,
pubmed-meshheading:18696160-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18696160-Thyroid Neoplasms,
pubmed-meshheading:18696160-Tissue Array Analysis
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pubmed:year |
2008
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pubmed:articleTitle |
The chemokine receptors CXCR4 and CCR7 are associated with tumor size and pathologic indicators of tumor aggressiveness in papillary thyroid carcinoma.
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pubmed:affiliation |
Department of Surgery, New York-Presbyterian Hospital/Weill Cornell Medical Center, 525 E. 68th St., K-707, New York, NY 10065, USA. plw9001@nyp.org
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pubmed:publicationType |
Journal Article
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