Source:http://linkedlifedata.com/resource/pubmed/id/18695899
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2008-8-12
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| pubmed:abstractText |
Tenascin-C is an extracellular matrix protein that plays an important role in cell proliferation, migration and tumor invasion in various types of cancer. However, few reports exist on tenascin-C expression in renal cell carcinoma (RCC). This study aimed to assess the prognostic significance of tenascin-C in clear cell RCC. Using immunohistochemistry, 137 formalin-fixed, paraffin-embedded tissue sections obtained from patients with clear cell RCC were examined for tenascin-C expression. Tenascin-C expression was observed in 55 (40.1%) of the 137 clear cell RCC sections. Tumor cells displayed membranous and/or cytoplasmic staining for tenascin-C. Tenascin-C expression was more prominent near the pseudocapsule of the tumor and around the tumor vessels. Tenascin-C expression was significantly associated with a higher stage (P=0.0065) and higher nuclear grade (P=0.0001). However, there was no correlation between the tenascin-C expression and venous involvement. The cancer-specific survival rate in patients with a tenascin-C-positive primary tumor was significantly lower than that in those with a tenascin-C-negative primary tumor in univariate analysis (P=0.0017). However, tenascin-C expression did not exhibit a significant value for cancer-related death in the Cox regression analysis. In patients with stage 1-3 disease, the 5-year metastasis-free rate in patients with the tenascin-C-positive primary tumor was significantly lower than that in those with the tenascin-C-negative primary tumor (67.8 vs. 88.5%, respectively; P=0.0038). The Cox regression analysis showed that tenascin-C expression is a significant predictor of metastasis (P=0.0345). The tenascin-C expression was strongly related to the stage, nuclear grade and 5-year metastasis-free rate. Therefore, tenascin-C expression may be a possible marker for the metastatic potential of clear cell RCC.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
1021-335X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
20
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
511-6
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| pubmed:meshHeading |
pubmed-meshheading:18695899-Adult,
pubmed-meshheading:18695899-Aged,
pubmed-meshheading:18695899-Aged, 80 and over,
pubmed-meshheading:18695899-Carcinoma, Renal Cell,
pubmed-meshheading:18695899-Cell Nucleus,
pubmed-meshheading:18695899-Cytoplasm,
pubmed-meshheading:18695899-Female,
pubmed-meshheading:18695899-Humans,
pubmed-meshheading:18695899-Immunoenzyme Techniques,
pubmed-meshheading:18695899-Kidney Neoplasms,
pubmed-meshheading:18695899-Male,
pubmed-meshheading:18695899-Middle Aged,
pubmed-meshheading:18695899-Neoplasm Invasiveness,
pubmed-meshheading:18695899-Neoplasm Recurrence, Local,
pubmed-meshheading:18695899-Neoplasm Staging,
pubmed-meshheading:18695899-Prognosis,
pubmed-meshheading:18695899-Survival Rate,
pubmed-meshheading:18695899-Tenascin,
pubmed-meshheading:18695899-Tumor Markers, Biological
|
| pubmed:year |
2008
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| pubmed:articleTitle |
Prognostic significance of tenascin-C expression in clear cell renal cell carcinoma.
|
| pubmed:affiliation |
Department of Urology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, Japan. yoshio-o@tokyo-med.ac.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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