Linked Life Data

18695513

Source:http://linkedlifedata.com/resource/pubmed/id/18695513

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2008-8-12
pubmed:abstractText
Nitric oxide and calcitonin gene-related peptide (CGRP) have been implicated in craniofacial pain including migraine headache, and CGRP induces face-grooming indicative of nocifensive behavior in animals. The aim of this study was to test whether systemic administration of nitroglycerin (NTG) influences the CGRP-induced behavior in awake rats and whether sumatriptan, a 5-HT1B/1D receptor agonist, can block the effects of NTG. CGRP was not significantly different from normal saline in inducing face-grooming behavior but NTG facilitated the effect of CGRP. Furthermore, sumatriptan was found to block the effect of NTG. These data suggest that facilitatory processes involving nitric oxide may be necessary for CGRP to play a role in some craniofacial pain conditions including possibly migraine headache.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1473-558X
pubmed:author
pubmed:issnType
Electronic
pubmed:day
27
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1307-11
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Nitroglycerin facilitates calcitonin gene-related peptide-induced behavior.
pubmed:affiliation
Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't