Linked Life Data

18692401

Source:http://linkedlifedata.com/resource/pubmed/id/18692401

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2008-8-25
pubmed:abstractText
Endocrine fibroblast growth factors (FGFs) control a variety of physiological processes including suppression of bile acid synthesis in hepatocytes, promotion of lipolysis in adipocytes, and inhibition of phosphate reabsorption and vitamin D biosynthesis in renal tubular cells. Endocrine FGFs require the Klotho gene family of transmembrane proteins as co-receptors to bind cognate FGF receptors. Importantly, expression of endocrine FGFs is regulated by nuclear receptors whose lipophilic ligands are generated under the control of these hormones in their target organs. Thus, novel endocrine axes have emerged that regulate diverse metabolic processes through feedback loops composed of the FGF, Klotho, and nuclear receptor gene families. This review covers roles of Klotho family proteins in the regulation of activity and expression of endocrine FGFs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1043-2760
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
239-45
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Endocrine FGFs and Klothos: emerging concepts.
pubmed:affiliation
Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75390-9072, USA. makoto.kuro-o@utsouthwestern.edu
pubmed:publicationType
Journal Article, Review