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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-9-5
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pubmed:abstractText |
Hypermethylation of promoter CpG islands is strongly correlated to transcriptional gene silencing and epigenetic maintenance of the silenced state. As well as its role in tumor development, CpG island methylation contributes to the acquisition of resistance to chemotherapy. Differential Methylation Hybridisation (DMH) is one technique used for genome-wide DNA methylation analysis. The study of such microarray data sets should ideally account for the specific biological features of DNA methylation and the non-symmetrical distribution of the ratios of unmethylated and methylated sequences hybridised on the array. We have therefore developed a novel algorithm tailored to this type of data, Methylation Linear Discriminant Analysis (MLDA).
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-11309499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-11731411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-11951657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-12011421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-12095276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-12114427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-12163706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-12724229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-15277367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-15302897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-16675572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-16900213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-17478416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-17504987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-17591626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-17599952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-17720884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-17875689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-18065728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-2423876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-2777259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-3656447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-7505451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-8640828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-8790415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18691414-9949205
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2105
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
337
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18691414-Algorithms,
pubmed-meshheading:18691414-Cell Line, Tumor,
pubmed-meshheading:18691414-Cisplatin,
pubmed-meshheading:18691414-CpG Islands,
pubmed-meshheading:18691414-DNA Methylation,
pubmed-meshheading:18691414-DNA Modification Methylases,
pubmed-meshheading:18691414-Discriminant Analysis,
pubmed-meshheading:18691414-Drug Resistance, Neoplasm,
pubmed-meshheading:18691414-Female,
pubmed-meshheading:18691414-Humans,
pubmed-meshheading:18691414-Linear Models,
pubmed-meshheading:18691414-Nucleic Acid Hybridization,
pubmed-meshheading:18691414-Ovarian Neoplasms
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pubmed:year |
2008
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pubmed:articleTitle |
Methylation Linear Discriminant Analysis (MLDA) for identifying differentially methylated CpG islands.
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pubmed:affiliation |
Ovarian Cancer Action Centre and Section of Epigenetics, Department of Oncology, Imperial College, Hammersmith Hospital, London, UK. w.dai@imperial.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural,
Validation Studies
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