Linked Life Data

18691096

Source:http://linkedlifedata.com/resource/pubmed/id/18691096

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
2008-8-11
pubmed:abstractText
The inability of present therapies to mitigate the devastating effects of sepsis and multiple organ failure in the critically ill patient indicates that more knowledge of the pathophysiology of sepsis is needed if we are to develop better, more effective interventions. This review will examine the concept that a portion of the immune and organ dysfunctions encountered in the septic rodent/ patient is a reflection of not only the types of cells stimulating/ mediating the apoptotic response, but also the varying capacity of the target cell in a given tissue/ organ to perceive these death receptor stimuli as either an apoptotic, inflammatory and/or necrotic signal. We hope the discussion of such studies provides not only new insight into the pathobiology of sepsis, but also suggests possible therapeutic targets for the management of this devastating condition.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1873-4286
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1853-9
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Apoptosis in sepsis: mechanisms, clinical impact and potential therapeutic targets.
pubmed:affiliation
Division of Surgical Research, Department of Surgery, Rhode Island Hospital/Brown University School of Medicine, Providence, RI 02903, USA. AAYALA@LIFESPAN.org
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural