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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-9-9
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pubmed:abstractText |
Restorative medicine has a constant need for improved scaffold materials. Degradable biopolymers often suffer from uncontrolled chemical or enzymatic hydrolysis by the host. The need for a second surgery on the other hand is a major drawback for nondegradable scaffold materials. In this paper we report the design and synthesis of a novel polysialic acid-based hydrogel with promising properties. Hydrogel synthesis was optimized and enzymatic degradation was studied using a phage-born endosialidase. After addition of endosialidase, hydrogels readily degraded depending on the amount of initially used cross-linker within 2 to 11 days. This polysialic acid hydrogel is not cytotoxic, completely stable under physiological conditions, and could be evaluated as growth support for PC12 cells. Here, additional coating with collagen I, poly-L-lysine or matrigel is mandatory to improve the properties of the material.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogels,
http://linkedlifedata.com/resource/pubmed/chemical/Laminin,
http://linkedlifedata.com/resource/pubmed/chemical/Neuraminidase,
http://linkedlifedata.com/resource/pubmed/chemical/Polylysine,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/Sialic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/endo-N-acetylneuraminidase,
http://linkedlifedata.com/resource/pubmed/chemical/matrigel,
http://linkedlifedata.com/resource/pubmed/chemical/polysialic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1526-4602
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2353-9
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pubmed:meshHeading |
pubmed-meshheading:18690740-Animals,
pubmed-meshheading:18690740-Cell Adhesion,
pubmed-meshheading:18690740-Cell Proliferation,
pubmed-meshheading:18690740-Cell Survival,
pubmed-meshheading:18690740-Cells, Cultured,
pubmed-meshheading:18690740-Collagen,
pubmed-meshheading:18690740-Collagen Type I,
pubmed-meshheading:18690740-Drug Combinations,
pubmed-meshheading:18690740-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:18690740-Hydrogels,
pubmed-meshheading:18690740-Hydrolysis,
pubmed-meshheading:18690740-Laminin,
pubmed-meshheading:18690740-Molecular Conformation,
pubmed-meshheading:18690740-Neuraminidase,
pubmed-meshheading:18690740-PC12 Cells,
pubmed-meshheading:18690740-Polylysine,
pubmed-meshheading:18690740-Proteoglycans,
pubmed-meshheading:18690740-Rats,
pubmed-meshheading:18690740-Sialic Acids,
pubmed-meshheading:18690740-Tissue Engineering
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pubmed:year |
2008
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pubmed:articleTitle |
Synthesis and biological evaluation of a polysialic acid-based hydrogel as enzymatically degradable scaffold material for tissue engineering.
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pubmed:affiliation |
Institut für Organische Chemie and Zentrum für Biomolekulare Wirkstoffe (BMWZ), Gottfried Willhelm Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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