Linked Life Data

1868908

Source:http://linkedlifedata.com/resource/pubmed/id/1868908

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-9-13
pubmed:abstractText
In this study, results show that applied electric currents can be effective to control the neuronal bursting that characterizes epileptic activity. Recordings from the CA1 region of rat hippocampus treated with penicillin show that local inhibition of epileptiform bursts is possible by short anodic current pulses (50 ms duration) applied extracellularly. Inhibition was evidenced by a large reduction (greater than 90%) in the amplitude of field potential. Data collected from 20 slices with moderate field potentials (50-80% of maximum) showed that current needed for complete inhibition was on the order of 42 +/- 3 microA. Intracellular recordings in CA1 cells (n = 13) showed that the decrease in field potential amplitude was accompanied by suppression of intracellular neuronal firing caused by somatic hyperpolarization as measured by transmembrane potentials. The resulting hyperpolarization was on the order of 13 mv below resting potential for weakly epileptiform responses (less than 50% of maximum response), and 50 mv below resting potential for strongly epileptiform activity (greater than 50% of maximum response). These results reveal the existence of a stimulation window within which inhibition of neuronal elements can be achieved without simultaneous excitation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0014-4886
pubmed:author
pubmed:issnType
Print
pubmed:volume
113
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
249-54
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Effects of applied currents on epileptiform bursts in vitro.
pubmed:affiliation
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106.
pubmed:publicationType
Journal Article, In Vitro