| pubmed-article:1868836 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1868836 | lifeskim:mentions | umls-concept:C0015154 | lld:lifeskim |
| pubmed-article:1868836 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:1868836 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:1868836 | lifeskim:mentions | umls-concept:C0037081 | lld:lifeskim |
| pubmed-article:1868836 | lifeskim:mentions | umls-concept:C1705822 | lld:lifeskim |
| pubmed-article:1868836 | lifeskim:mentions | umls-concept:C0600448 | lld:lifeskim |
| pubmed-article:1868836 | lifeskim:mentions | umls-concept:C0348011 | lld:lifeskim |
| pubmed-article:1868836 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:1868836 | pubmed:dateCreated | 1991-9-18 | lld:pubmed |
| pubmed-article:1868836 | pubmed:abstractText | Very closely related short sequences are present at the 5' end of cytoplasmic mRNAs in Euglena as evidenced by comparison of cDNA sequences and hybrid-arrested translation experiments. By cloning Euglena gracilis nuclear DNA and isolating the rbcS gene (encoding the small subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase), we have shown that the short leader sequence does not flank the nuclear gene sequence. The leader sequences were found to constitute the 5' extremities of a family of small RNAs. Sequencing six members of this family revealed a striking similarity to vertebrate U snRNAs. We propose that a trans-splicing mechanism transfers the spliced leader (SL) sequence from these small RNAs (SL RNAs) to pre-mature mRNAs. Transfer of leader sequences to mRNAs by trans-splicing has been shown only in trypanosomes where cis-splicing is unknown, and in nematodes where not more than 10% of the mRNAs have leader sequences. Our results strongly suggest that Euglena is a unique organism in which both a widespread trans-splicing and a cis-splicing mechanism co-exist. | lld:pubmed |
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| pubmed-article:1868836 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1868836 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1868836 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1868836 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1868836 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1868836 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:1868836 | pubmed:author | pubmed-author:KellerMM | lld:pubmed |
| pubmed-article:1868836 | pubmed:author | pubmed-author:WeilJ HJH | lld:pubmed |
| pubmed-article:1868836 | pubmed:author | pubmed-author:ImbaultPP | lld:pubmed |
| pubmed-article:1868836 | pubmed:author | pubmed-author:FournierRR | lld:pubmed |
| pubmed-article:1868836 | pubmed:author | pubmed-author:ChanR LRL | lld:pubmed |
| pubmed-article:1868836 | pubmed:author | pubmed-author:TessierL HLH | lld:pubmed |
| pubmed-article:1868836 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1868836 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:1868836 | pubmed:geneSymbol | rbcS | lld:pubmed |
| pubmed-article:1868836 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1868836 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1868836 | pubmed:pagination | 2621-5 | lld:pubmed |
| pubmed-article:1868836 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1868836 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1868836 | pubmed:articleTitle | Short leader sequences may be transferred from small RNAs to pre-mature mRNAs by trans-splicing in Euglena. | lld:pubmed |
| pubmed-article:1868836 | pubmed:affiliation | Institut de Biologie Moléculaire des Plantes du CNRS, Université Louis Pasteur, Strasbourg, France. | lld:pubmed |
| pubmed-article:1868836 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1868836 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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