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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-9-12
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pubmed:abstractText |
Age-related macular degeneration (ARMD) and Alzheimer's disease (AD) are neurodegenerative disorders that share a high prevalence among elderly people, the extracellular deposition of beta-amyloid and the involvement of genetic factors in their aetiology. Genetic linkage with the chromosome regions 10q26 and 10q24-25 have been shown for ARMD and AD, respectively. The rs10490924 polymorphism, the major determinant of the 10q26 association with ARMD, determines the A69S substitution in the LOC387715/ARMS2 gene. Little information is available about the expression of the gene in humans.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1421-9824
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2008 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
169-74
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pubmed:meshHeading |
pubmed-meshheading:18688167-Aged,
pubmed-meshheading:18688167-Aged, 80 and over,
pubmed-meshheading:18688167-Alzheimer Disease,
pubmed-meshheading:18688167-Apolipoprotein E4,
pubmed-meshheading:18688167-Female,
pubmed-meshheading:18688167-Gene Frequency,
pubmed-meshheading:18688167-Genetic Predisposition to Disease,
pubmed-meshheading:18688167-Humans,
pubmed-meshheading:18688167-Macular Degeneration,
pubmed-meshheading:18688167-Male,
pubmed-meshheading:18688167-Middle Aged,
pubmed-meshheading:18688167-Polymorphism, Genetic,
pubmed-meshheading:18688167-Proteins,
pubmed-meshheading:18688167-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18688167-Risk Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Polymorphisms in the LOC387715/ARMS2 putative gene and the risk for Alzheimer's disease.
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pubmed:affiliation |
Section of Biochemistry, Faculty of Medicine, University of Brescia, Brescia, Italy.
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pubmed:publicationType |
Journal Article
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