Linked Life Data

18688112

Source:http://linkedlifedata.com/resource/pubmed/id/18688112

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2008-8-8
pubmed:abstractText
Mycobacterium tuberculosis is the leading cause of death from a single bacterial species in the world and is subjected to a highly oxidative environment in its host macrophage and consequently has evolved protective mechanisms against reactive oxygen and nitrogen intermediates. Alkyl hydroperoxidase D (AhpD) is a molecule from these mycobacterial defense systems that has a dual function. It not only works with Alkyl hydroperoxidase C (AhpC) in mycobacterial defense system against oxidative stress but also has a role in oxidation/reduction of succinyltransferase B (SucB), dihydrolipoamide dehydrogenase (LPD) and AhpC. The present study was undertaken to find out the effects of inactivation of ahpD gene in the intra-macrophage persistence of resulted BCG mutant.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0019-5359
pubmed:author
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
275-82
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Mutation in alkylhydroperoxidase D gene dramatically decreases persistence of Mycobacterium bovis bacillus calmette-guerin in infected macrophage.
pubmed:affiliation
School of Medicine, Research Institute for Tropical Medicine and Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran. taghin@yahoo.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't