| pubmed-article:18687808 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18687808 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:18687808 | lifeskim:mentions | umls-concept:C0221920 | lld:lifeskim |
| pubmed-article:18687808 | lifeskim:mentions | umls-concept:C0003018 | lld:lifeskim |
| pubmed-article:18687808 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:18687808 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:18687808 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:18687808 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:18687808 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:18687808 | pubmed:dateCreated | 2008-10-21 | lld:pubmed |
| pubmed-article:18687808 | pubmed:abstractText | Caveolin1 (Cav1) is an important component of the plasmamembrane microdomains, such as caveolae/lipid rafts, that are associated with angiotensin II type 1 (AT(1)) and epidermal growth factor (EGF) receptors in certain cell types. The interactions of Cav1 with other signaling molecules that mediate AT(1) receptor function were analyzed in angiotensin II (Ang II)- and EGF-stimulated hepatic C9 cells. This study demonstrated that cholesterol-rich domains mediate the actions of early upstream signaling molecules such as Src and intracellular Ca(2+) in cells stimulated by Ang II, but not by EGF, and that Cav1 has a scaffolding role in the process of mitogen-activated protein kinase activation. Furthermore, Cav1 phosphorylation by Ang II and EGF was regulated by intracellular Ca(2+) and Src, further indicating reciprocal interactions among Cav1, Src, and intracellular Ca(2+) through the AT(1) receptor. Phosphorylation of Cav1 and the EGF receptor by Ang II, but not of extracellular signal-regulated kinase 1/2, was dependent on intracellular Ca(2+). The phosphatidylinositol 3-kinase inhibitors, 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride (LY294002) and wortmannin, differentially modulated both Cav1 and EGF receptor activation by Ang II through intracellular Ca(2+). These findings further demonstrate the importance of Cav1 in conjunction with the receptor-mediated signaling pathways involved in cell proliferation and survival. It is clear that differential signaling pathways are operative in Ang II- and EGF-stimulated C9 cells and that cholesterol-enriched microdomains are essential components in cellular signaling processes that are dependent on specific agonists and/or cell types. | lld:pubmed |
| pubmed-article:18687808 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18687808 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18687808 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18687808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18687808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18687808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18687808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18687808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18687808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18687808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18687808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18687808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18687808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18687808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18687808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18687808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18687808 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18687808 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:18687808 | pubmed:issn | 1521-0111 | lld:pubmed |
| pubmed-article:18687808 | pubmed:author | pubmed-author:CattKevin JKJ | lld:pubmed |
| pubmed-article:18687808 | pubmed:author | pubmed-author:HanJ-HJH | lld:pubmed |
| pubmed-article:18687808 | pubmed:author | pubmed-author:YinXingX | lld:pubmed |
| pubmed-article:18687808 | pubmed:author | pubmed-author:ChenHungdarH | lld:pubmed |
| pubmed-article:18687808 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18687808 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:18687808 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18687808 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18687808 | pubmed:pagination | 1223-33 | lld:pubmed |
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| pubmed-article:18687808 | pubmed:meshHeading | pubmed-meshheading:18687808... | lld:pubmed |
| pubmed-article:18687808 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18687808 | pubmed:articleTitle | Differential signaling pathways in angiotensin II- and epidermal growth factor-stimulated hepatic C9 cells. | lld:pubmed |
| pubmed-article:18687808 | pubmed:affiliation | Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:18687808 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18687808 | lld:pubmed |
