Source:http://linkedlifedata.com/resource/pubmed/id/18687808
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2008-10-21
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| pubmed:abstractText |
Caveolin1 (Cav1) is an important component of the plasmamembrane microdomains, such as caveolae/lipid rafts, that are associated with angiotensin II type 1 (AT(1)) and epidermal growth factor (EGF) receptors in certain cell types. The interactions of Cav1 with other signaling molecules that mediate AT(1) receptor function were analyzed in angiotensin II (Ang II)- and EGF-stimulated hepatic C9 cells. This study demonstrated that cholesterol-rich domains mediate the actions of early upstream signaling molecules such as Src and intracellular Ca(2+) in cells stimulated by Ang II, but not by EGF, and that Cav1 has a scaffolding role in the process of mitogen-activated protein kinase activation. Furthermore, Cav1 phosphorylation by Ang II and EGF was regulated by intracellular Ca(2+) and Src, further indicating reciprocal interactions among Cav1, Src, and intracellular Ca(2+) through the AT(1) receptor. Phosphorylation of Cav1 and the EGF receptor by Ang II, but not of extracellular signal-regulated kinase 1/2, was dependent on intracellular Ca(2+). The phosphatidylinositol 3-kinase inhibitors, 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride (LY294002) and wortmannin, differentially modulated both Cav1 and EGF receptor activation by Ang II through intracellular Ca(2+). These findings further demonstrate the importance of Cav1 in conjunction with the receptor-mediated signaling pathways involved in cell proliferation and survival. It is clear that differential signaling pathways are operative in Ang II- and EGF-stimulated C9 cells and that cholesterol-enriched microdomains are essential components in cellular signaling processes that are dependent on specific agonists and/or cell types.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-(4-morpholinyl)-8-phenyl-4H-1-benz...,
http://linkedlifedata.com/resource/pubmed/chemical/Androstadienes,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Chromones,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Filipin,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholines,
http://linkedlifedata.com/resource/pubmed/chemical/Nystatin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/wortmannin
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
1521-0111
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
74
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1223-33
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| pubmed:meshHeading |
pubmed-meshheading:18687808-Androstadienes,
pubmed-meshheading:18687808-Angiotensin II,
pubmed-meshheading:18687808-Base Sequence,
pubmed-meshheading:18687808-Calcium,
pubmed-meshheading:18687808-Cell Line,
pubmed-meshheading:18687808-Cholesterol,
pubmed-meshheading:18687808-Chromones,
pubmed-meshheading:18687808-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:18687808-Enzyme Inhibitors,
pubmed-meshheading:18687808-Epidermal Growth Factor,
pubmed-meshheading:18687808-Filipin,
pubmed-meshheading:18687808-Humans,
pubmed-meshheading:18687808-Liver,
pubmed-meshheading:18687808-Morpholines,
pubmed-meshheading:18687808-Nystatin,
pubmed-meshheading:18687808-Phosphorylation,
pubmed-meshheading:18687808-RNA, Small Interfering,
pubmed-meshheading:18687808-Signal Transduction
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| pubmed:year |
2008
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| pubmed:articleTitle |
Differential signaling pathways in angiotensin II- and epidermal growth factor-stimulated hepatic C9 cells.
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| pubmed:affiliation |
Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
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| pubmed:publicationType |
Journal Article
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