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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2009-9-1
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pubmed:abstractText |
A formal total synthesis of the potent anticancer agent Et-743 is described. The tetrahydroisoquinoline core is stereoselectively constructed using a novel radical cyclization of a glyoxalimine. Further elaboration of this core rapidly accessed the pentacyclic core of Et-743, but a mixture of regiosisomers was obtained in the key Pictet-Spengler ring closure. A known advanced intermediate in the synthesis of Et-743 was intercepted, constituting a formal synthesis of the molecule.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18687003-10956543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18687003-11902886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18687003-11996547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18687003-12047173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18687003-12172500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18687003-12790537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18687003-15903318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18687003-16144418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18687003-16390134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18687003-16632360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18687003-16836390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18687003-17387658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18687003-2095373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18687003-4032430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18687003-8318161
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1520-6904
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
19
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9594-600
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pubmed:dateRevised |
2011-4-25
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pubmed:meshHeading |
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pubmed:year |
2008
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pubmed:articleTitle |
Synthetic studies on Et-743. Assembly of the pentacyclic core and a formal total synthesis.
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pubmed:affiliation |
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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