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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2008-8-28
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pubmed:abstractText |
In this work we report a new type of pH-responsive micelle-like nanoparticle. Reversible nanoscale structures are formed in solutions of a pH-sensitive hydrophobic polyelectrolyte, poly( N-methacryloyl- l-valine) or poly( N-methacryloyl- l-phenylalanine), and nonionic surfactant (Brij 98) in the presence of hydrochloric acid. The influence of composition and pH on particles size and shape was investigated by a variety of methods. An entity's size and polydispersity could be varied in a broad range making them a perspective candidate as a drug carrier. Unlike the case of typical micelles, our results indicate the presence of cavities in the formed particles. A hypothetical model of a nanoparticle and mechanism of formation are proposed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0743-7463
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9295-301
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pubmed:meshHeading |
pubmed-meshheading:18686981-Electrolytes,
pubmed-meshheading:18686981-Hydrogen-Ion Concentration,
pubmed-meshheading:18686981-Ions,
pubmed-meshheading:18686981-Light,
pubmed-meshheading:18686981-Micelles,
pubmed-meshheading:18686981-Microscopy, Atomic Force,
pubmed-meshheading:18686981-Models, Chemical,
pubmed-meshheading:18686981-Nanoparticles,
pubmed-meshheading:18686981-Nanotechnology,
pubmed-meshheading:18686981-Phenylalanine,
pubmed-meshheading:18686981-Plant Oils,
pubmed-meshheading:18686981-Polyethylene Glycols,
pubmed-meshheading:18686981-Polymers,
pubmed-meshheading:18686981-Scattering, Radiation,
pubmed-meshheading:18686981-Surface Properties,
pubmed-meshheading:18686981-Valine
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pubmed:year |
2008
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pubmed:articleTitle |
Novel pH-responsive nanoparticles.
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pubmed:affiliation |
Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic. filippov@imc.cas.cz
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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