Linked Life Data

1868610

Source:http://linkedlifedata.com/resource/pubmed/id/1868610

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1991-9-19
pubmed:abstractText
Two families with benign hyperphosphatasemia of intestinal origin were studied and compared with six other cases reported in the literature. No evidence of clinical abnormalities or explanations for the unusual enzyme concentrations were found. Agarose gel electrophoresis of alkaline phosphatase (ALP, EC 3.1.3.1) isoenzymes in serum demonstrated markedly increased intestinal isoforms (the "soluble" and the "hydrophobic" forms), which accounted for approximately 60% of total ALP activity. The description of these families demonstrated patterns suggesting autosomal-dominant inheritance, even if the precise genetic background of the abnormality affecting the enzyme production or the control mechanisms for its entry into the circulation could not be determined. Exact recognition of this benign biochemical abnormality should help to avoid unnecessary investigation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0009-9147
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1449-52
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Benign inherited hyperphosphatasemia of intestinal origin: report of two cases and a brief review of the literature.
pubmed:affiliation
1 Laboratorio Analisi Chimico-Cliniche, Spedali Civili, Brescia, Italy.
pubmed:publicationType
Journal Article, Review, Case Reports