Linked Life Data

18686090

Source:http://linkedlifedata.com/resource/pubmed/id/18686090

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2008-9-18
pubmed:abstractText
The purpose of these studies was to investigate the ability of surface energy measurements and rates of mixing in dry powder inhaler (DPI) formulations to predict aerosol dispersion performance. Two lactose carrier systems comprising either spray-dried or milled particles were developed such that they had identical physical characteristics except for surface morphology and surface energies avoiding confounding variables common in other studies. Surface energy measurements confirmed significant differences between the powder systems. Spray-dried lactose had a higher surface entropy (0.20 vs. 0.13 mJ/m(2)K) and surface enthalpy (103.2 vs. 79.2 mJ/m(2)) compared with milled lactose. Mixing rates of budesonide or fluorescein were assessed dynamically, and significant differences in blending were observed between lactose systems for both drugs. Surface energies of the lactose carriers were inversely proportional to dispersion performance. In addition, the root mean square (RMS) of blending rates correlated positively with aerosol dispersion performance. Both techniques have potential utility in routine screening of DPI formulations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1520-5762
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1002-10
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Prediction of dry powder inhaler formulation performance from surface energetics and blending dynamics.
pubmed:affiliation
College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't