Source:http://linkedlifedata.com/resource/pubmed/id/18680694
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
2008-8-5
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pubmed:abstractText |
Hypersensitivity reactions to abacavir occur in 5-8% of patients starting treatment with this drug and limits future treatment. Some host genetic factors, especially the HLA-B*5701 allele, have been identified as risk factors for hypersensitivity reaction in Caucasians. Consequently, the possibility of routine implementation of a genetic test to rule out the presence of this allele has been proposed to achieve a personalized therapeutic profile. The present article discusses all the information related to hypersensitivity to abacavir and its genetic and immunological markers, as well as the distinct techniques for HLA-B*5701 allele detection. The various studies performed to date in distinct population are also discussed.
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pubmed:commentsCorrections | |
pubmed:language |
spa
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-HIV Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Dideoxynucleosides,
http://linkedlifedata.com/resource/pubmed/chemical/Genetic Markers,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/abacavir
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0213-005X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
26 Suppl 6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
34-9
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pubmed:dateRevised |
2009-2-19
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pubmed:meshHeading |
pubmed-meshheading:18680694-Alleles,
pubmed-meshheading:18680694-Anti-HIV Agents,
pubmed-meshheading:18680694-Dideoxynucleosides,
pubmed-meshheading:18680694-Drug Hypersensitivity,
pubmed-meshheading:18680694-Genetic Markers,
pubmed-meshheading:18680694-Genetic Predisposition to Disease,
pubmed-meshheading:18680694-HIV Infections,
pubmed-meshheading:18680694-HLA-B Antigens,
pubmed-meshheading:18680694-Humans
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pubmed:year |
2008
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pubmed:articleTitle |
[HLA-B*5701 and hypersensitivity reactions to abacavir. Study methods and clinical relevance].
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pubmed:affiliation |
Servicio de Infecciosas, Hospital Clínic, IDIBAPS, Barcelona, España. marnedo@clinic.ub.es
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pubmed:publicationType |
Journal Article,
English Abstract
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