Linked Life Data

18680694

Source:http://linkedlifedata.com/resource/pubmed/id/18680694

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-8-5
pubmed:abstractText
Hypersensitivity reactions to abacavir occur in 5-8% of patients starting treatment with this drug and limits future treatment. Some host genetic factors, especially the HLA-B*5701 allele, have been identified as risk factors for hypersensitivity reaction in Caucasians. Consequently, the possibility of routine implementation of a genetic test to rule out the presence of this allele has been proposed to achieve a personalized therapeutic profile. The present article discusses all the information related to hypersensitivity to abacavir and its genetic and immunological markers, as well as the distinct techniques for HLA-B*5701 allele detection. The various studies performed to date in distinct population are also discussed.
pubmed:commentsCorrections
pubmed:language
spa
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0213-005X
pubmed:author
pubmed:issnType
Print
pubmed:volume
26 Suppl 6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
34-9
pubmed:dateRevised
2009-2-19
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
[HLA-B*5701 and hypersensitivity reactions to abacavir. Study methods and clinical relevance].
pubmed:affiliation
Servicio de Infecciosas, Hospital Clínic, IDIBAPS, Barcelona, España. marnedo@clinic.ub.es
pubmed:publicationType
Journal Article, English Abstract