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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2008-8-25
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pubmed:abstractText |
A series of ring expanded nucleoside (REN) analogues were synthesized and screened for inhibition of cellular RNA helicase activity and human immunodeficiency virus type 1 (HIV-1) replication. We identified two compounds, 1 and 2, that inhibited the ATP dependent activity of human RNA helicase DDX3. Compounds 1 and 2 also suppressed HIV-1 replication in T cells and monocyte-derived macrophages. Neither compound at therapeutic doses was significantly toxic in ex vivo cell culture or in vivo in mice. Our findings provide proof-of-concept that a cellular factor, an RNA helicase, could be targeted for inhibiting HIV-1 replication.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-10502801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-11329852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-11545728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-11642367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-11728322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-11927945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-11927946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-12110176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-12438396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-12694177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-12737640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-12954067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-14561097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-14598316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-14623539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-14645903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-14991003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-15371436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-15507209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-15596808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-15780141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-16184083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-16893449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-16935887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-17034647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-17169163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-17961213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-18086417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-18187620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-2563148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-3257102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-9334325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-9491887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18680273-9747670
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1520-4804
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
28
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5043-51
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18680273-Animals,
pubmed-meshheading:18680273-Azepines,
pubmed-meshheading:18680273-Cell Line,
pubmed-meshheading:18680273-DEAD-box RNA Helicases,
pubmed-meshheading:18680273-Enzyme Inhibitors,
pubmed-meshheading:18680273-HIV-1,
pubmed-meshheading:18680273-Humans,
pubmed-meshheading:18680273-Mice,
pubmed-meshheading:18680273-Nucleosides,
pubmed-meshheading:18680273-Stereoisomerism,
pubmed-meshheading:18680273-Virus Replication
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pubmed:year |
2008
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pubmed:articleTitle |
Ring expanded nucleoside analogues inhibit RNA helicase and intracellular human immunodeficiency virus type 1 replication.
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pubmed:affiliation |
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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