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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2008-9-4
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pubmed:abstractText |
Series of curcumin derivatives were synthesized; the inhibitory activities on thioredoxin reductase (TrxR) of all analogues were evaluated by DTNB assay in vitro. It is found that most of the analogues can inhibit TrxR in the low micromolar range; Structure-activity relationship analysis reveals that analogues with furan moiety have excellent inhibitory effect on TrxR in an irreversible manner, indicating that the furan moiety may serve as a possible pharmacophore during the interaction of curcumin analogues with TrxR. The effect of selected curcuminoids on growth of different TrxR overexpressed cancer cell lines was also investigated and discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1464-3391
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pubmed:author |
pubmed-author:AnLin-KunLK,
pubmed-author:BuXian-ZhangXZ,
pubmed-author:GuLian-QuanLQ,
pubmed-author:HuangShi-LiangSL,
pubmed-author:HuangZhi-ShuZS,
pubmed-author:JingDa-PingDP,
pubmed-author:LiuXingX,
pubmed-author:LiuZhongZ,
pubmed-author:OofFF,
pubmed-author:ShaoWei-YanWY,
pubmed-author:YuYan-JunYJ
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8035-41
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pubmed:meshHeading |
pubmed-meshheading:18678491-Antineoplastic Agents,
pubmed-meshheading:18678491-Cell Proliferation,
pubmed-meshheading:18678491-Curcumin,
pubmed-meshheading:18678491-Dose-Response Relationship, Drug,
pubmed-meshheading:18678491-Drug Screening Assays, Antitumor,
pubmed-meshheading:18678491-Enzyme Inhibitors,
pubmed-meshheading:18678491-Furans,
pubmed-meshheading:18678491-Humans,
pubmed-meshheading:18678491-Molecular Structure,
pubmed-meshheading:18678491-Stereoisomerism,
pubmed-meshheading:18678491-Structure-Activity Relationship,
pubmed-meshheading:18678491-Thioredoxin-Disulfide Reductase,
pubmed-meshheading:18678491-Tumor Cells, Cultured
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pubmed:year |
2008
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pubmed:articleTitle |
Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors.
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pubmed:affiliation |
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510275, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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