Linked Life Data

18677935

Source:http://linkedlifedata.com/resource/pubmed/id/18677935

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-8-5
pubmed:abstractText
The scientific literature states that isatin and its derivatives exhibit antibacterial, antifungal, anticonvulsant, cytotoxic and anti-HIV activities. The aim of our study was to enlarge the number of isatin derivatives. MATERIAL AND METHOD: We synthesized some new hydrazones and then, the corresponding bishydrazones using salicylaldehyde. By condensing isatin and its derivatives (methyl-, nitro-, brom-) with hydrazine, corresponding hydrazones were obtained. The bishydrazones were synthesized by refluxing the obtained hydrazones with salicylaldehyde in methanolic solution. The structure of new compounds was confirmed by elemental and spectral analysis. The lipophilicity of the synthesized derivatives was expressed by clog P values. The antibacterial and antifungal activities of the compounds were determined using disk-diffusion method against Gram positive, Gram negative bacteria, and Candida albicans. RESULTS: New bishydrazines derived from isatin have been synthesized; their structures have been confirmed by elemental and spectral analysis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0048-7848
pubmed:author
pubmed:issnType
Print
pubmed:volume
112
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
246-8
pubmed:dateRevised
2011-1-13
pubmed:meshHeading
pubmed:articleTitle
Synthesis and characterization of some new bishydrazones derived from isatin.
pubmed:affiliation
Gr.T.Popa University of Medicine and Pharmacy Ia?i, School of Pharmacy.
pubmed:publicationType
Journal Article