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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2009-1-23
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pubmed:abstractText |
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 x 10(-4)), and the overall pattern of replication was unlikely to occur by chance (P = 9 x 10(-8)). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9)).
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1061-4036
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pubmed:author |
pubmed-author:AminFarooqF,
pubmed-author:BlackDonald WDW,
pubmed-author:BuccolaNancy GNG,
pubmed-author:ByerleyWilliam FWF,
pubmed-author:CarrollLiamL,
pubmed-author:CichonSvenS,
pubmed-author:CloningerC RobertCR,
pubmed-author:CorvinAidenA,
pubmed-author:CraddockNicholasN,
pubmed-author:DarvasiArielA,
pubmed-author:DuanJubaoJ,
pubmed-author:DwyerSarahS,
pubmed-author:FengGuoYinG,
pubmed-author:FreedmanRobertR,
pubmed-author:GejmanPablo VPV,
pubmed-author:GeorgievaLyudmilaL,
pubmed-author:GieglingInaI,
pubmed-author:GillMichaelM,
pubmed-author:HamshereMarianM,
pubmed-author:HartmannAnnette MAM,
pubmed-author:HeLinL,
pubmed-author:HoffmannPerP,
pubmed-author:HolmansPeterP,
pubmed-author:HowieBryanB,
pubmed-author:IkedaMasashiM,
pubmed-author:IwataNakaoN,
pubmed-author:KirovGeorgeG,
pubmed-author:LeungHin-TakHT,
pubmed-author:LevinsonDouglas FDF,
pubmed-author:MöllerHans-JürgenHJ,
pubmed-author:MaierWolfgangW,
pubmed-author:MarchiniJonathan LJL,
pubmed-author:Molecular Genetics of Schizophrenia Collaboration,
pubmed-author:MorrisDerek WDW,
pubmed-author:MoskvinaValentinaV,
pubmed-author:MowryBryan JBJ,
pubmed-author:NöthenMarkus MMM,
pubmed-author:NikolovIvanI,
pubmed-author:NortonNadineN,
pubmed-author:O'DonovanMichael CMC,
pubmed-author:OwenMichael JMJ,
pubmed-author:PeirceTimothyT,
pubmed-author:ProppingPeterP,
pubmed-author:QuinnEmma MEM,
pubmed-author:RietschelMarcellaM,
pubmed-author:RujescuDanD,
pubmed-author:SandersAlan RAR,
pubmed-author:SchulzeThomas GTG,
pubmed-author:SchumacherJohannesJ,
pubmed-author:ShiYongyongY,
pubmed-author:ShifmanSagivS,
pubmed-author:SilvermanJeremy MJM,
pubmed-author:SpencerChris C ACC,
pubmed-author:VasilescuCatalinaC,
pubmed-author:WilliamsHywelH,
pubmed-author:WilliamsNigel MNM,
pubmed-author:ZammitStanleyS
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1053-5
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pubmed:dateRevised |
2011-4-13
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pubmed:meshHeading |
pubmed-meshheading:18677311-Bipolar Disorder,
pubmed-meshheading:18677311-Case-Control Studies,
pubmed-meshheading:18677311-Chromosome Mapping,
pubmed-meshheading:18677311-Follow-Up Studies,
pubmed-meshheading:18677311-Genetic Predisposition to Disease,
pubmed-meshheading:18677311-Genome-Wide Association Study,
pubmed-meshheading:18677311-Humans,
pubmed-meshheading:18677311-Kruppel-Like Transcription Factors,
pubmed-meshheading:18677311-Polymorphism, Single Nucleotide,
pubmed-meshheading:18677311-Schizophrenia
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pubmed:year |
2008
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pubmed:articleTitle |
Identification of loci associated with schizophrenia by genome-wide association and follow-up.
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pubmed:affiliation |
Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK. wpcmod@cf.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Meta-Analysis
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