18676885

Source:http://linkedlifedata.com/resource/pubmed/id/18676885

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0021311, umls-concept:C0087111, umls-concept:C0175668, umls-concept:C0319899, umls-concept:C0439590, umls-concept:C0537894, umls-concept:C0683598, umls-concept:C1527148, umls-concept:C1609535
pubmed:issue	10
pubmed:dateCreated	2008-9-25
pubmed:abstractText	We report a case of Candida glabrata invasive candidiasis that developed reduced susceptibility to caspofungin during prolonged therapy. Pre- and posttreatment isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed an F659V substitution within the FKS2 region of the glucan synthase complex.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/5R01DE018096, http://linkedlifedata.com/resource/pubmed/grant/R01 DE018096-01, http://linkedlifedata.com/resource/pubmed/grant/R01 DE018096-02, http://linkedlifedata.com/resource/pubmed/grant/R01 DE018096-03
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0315061
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antifungal Agents, http://linkedlifedata.com/resource/pubmed/chemical/DNA, Fungal, http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers, http://linkedlifedata.com/resource/pubmed/chemical/Echinocandins, http://linkedlifedata.com/resource/pubmed/chemical/Glucosyltransferases, http://linkedlifedata.com/resource/pubmed/chemical/caspofungin, http://linkedlifedata.com/resource/pubmed/chemical/glucan synthase
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	1098-6596
pubmed:author	pubmed-author:JordanovaVV, pubmed-author:LewisJames SJS2nd, pubmed-author:PattersonThomas FTF, pubmed-author:VallorAna CAC, pubmed-author:VillarealNyria CNC, pubmed-author:WiederholdNathan PNP
pubmed:issnType	Electronic
pubmed:volume	52
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	3783-5
pubmed:dateRevised	2011-9-26
pubmed:meshHeading	pubmed-meshheading:18676885-Adult, pubmed-meshheading:18676885-Amino Acid Substitution, pubmed-meshheading:18676885-Antifungal Agents, pubmed-meshheading:18676885-Base Sequence, pubmed-meshheading:18676885-Candida glabrata, pubmed-meshheading:18676885-Candidiasis, pubmed-meshheading:18676885-DNA, Fungal, pubmed-meshheading:18676885-DNA Primers, pubmed-meshheading:18676885-Drug Resistance, Fungal, pubmed-meshheading:18676885-Echinocandins, pubmed-meshheading:18676885-Genes, Fungal, pubmed-meshheading:18676885-Glucosyltransferases, pubmed-meshheading:18676885-Humans
pubmed:year	2008
pubmed:articleTitle	Development of caspofungin resistance following prolonged therapy for invasive candidiasis secondary to Candida glabrata infection.
pubmed:affiliation	Department of Internal Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. thompsong2@uthscsa.edu
pubmed:publicationType	Journal Article, Case Reports, Research Support, N.I.H., Extramural