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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2008-8-4
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pubmed:abstractText |
The pathogenic CHEK2 1100delC variant is firmly established as a breast cancer susceptibility allele. Dutch CHEK2 1100delC breast cancer families frequently also include colorectal cancer cases, and the variant is particularly prevalent among breast cancer families with hereditary breast and colorectal cancer. Yet, it is still unclear whether CHEK2 1100delC also confers a colorectal cancer risk independent of its breast cancer risk.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1078-0432
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4989-94
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:18676774-Aged,
pubmed-meshheading:18676774-Alleles,
pubmed-meshheading:18676774-Case-Control Studies,
pubmed-meshheading:18676774-Cohort Studies,
pubmed-meshheading:18676774-Colorectal Neoplasms,
pubmed-meshheading:18676774-Colorectal Neoplasms, Hereditary Nonpolyposis,
pubmed-meshheading:18676774-Family Health,
pubmed-meshheading:18676774-Female,
pubmed-meshheading:18676774-Genetic Predisposition to Disease,
pubmed-meshheading:18676774-Genetic Variation,
pubmed-meshheading:18676774-Genotype,
pubmed-meshheading:18676774-Humans,
pubmed-meshheading:18676774-Male,
pubmed-meshheading:18676774-Middle Aged,
pubmed-meshheading:18676774-Protein-Serine-Threonine Kinases,
pubmed-meshheading:18676774-Risk
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pubmed:year |
2008
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pubmed:articleTitle |
CHEK2 1100delC is a susceptibility allele for HNPCC-related colorectal cancer.
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pubmed:affiliation |
Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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