Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2008-8-29
pubmed:abstractText
Identifying distinctions between pathogenic HIV and simian immunodeficiency virus (SIV) infections and nonprogressive SIV in natural African primate hosts might provide key insights into HIV pathogenesis. Similar to pathogenic HIV infection in humans, natural SIV infections result in high viral replication and massive acute depletion of mucosal CD4(+) T cells. A key distinction of natural SIV infections is a rapidly developing anti-inflammatory milieu that prevents chronic activation, apoptosis and proliferation of T cells and preserves the function of other immune cell subsets, thus contributing to the integrity of the mucosal barrier and the lack of microbial translocation from the gut to the peritoneum. Immunologic features observed during natural SIV infections suggest approaches for designing new strategies for producing novel second-generation vaccines and therapeutic approaches to inhibit disease progression in HIV-infected humans.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/P20 RR020159, http://linkedlifedata.com/resource/pubmed/grant/P20 RR020159-066760, http://linkedlifedata.com/resource/pubmed/grant/R01 AI035522, http://linkedlifedata.com/resource/pubmed/grant/R01 AI064066, http://linkedlifedata.com/resource/pubmed/grant/R01 AI064066-04, http://linkedlifedata.com/resource/pubmed/grant/R01 AI065325, http://linkedlifedata.com/resource/pubmed/grant/R01 AI065325-03, http://linkedlifedata.com/resource/pubmed/grant/R01 AI066998, http://linkedlifedata.com/resource/pubmed/grant/R21 AI060451, http://linkedlifedata.com/resource/pubmed/grant/R21 AI069935-02, http://linkedlifedata.com/resource/pubmed/grant/R21AI069935, http://linkedlifedata.com/resource/pubmed/grant/RR-00165, http://linkedlifedata.com/resource/pubmed/grant/RR-00168
pubmed:commentsCorrections
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pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
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