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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2008-8-4
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pubmed:abstractText |
Hirschsprung's disease (HSCR)-associated enterocolitis (HAEC) remains a major contributor to morbidity and mortality associated with HSCR, being sometimes difficult to diagnose in its subclinical form. Its pathogenesis appears to include impaired local defense mechanisms as well as dysfunctional immune response and leukocyte function. In this context, the ITGB2 (CD18) immunomodulation-related gene is a possible candidate in HAEC pathogenesis as it codes for the beta-subunit of leukocyte adhesion molecule lymphocyte function-associated antigen 1, which has an established role in T-cell development and function. ITGB2/CD18 has also been linked to chronic colitis in both human and animal models involving defense mechanisms within colonic mucosa. There is therefore a fairly compelling case for the potential involvement of the ITGB2 (CD18) in HAEC pathogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1531-5037
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1439-44
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18675632-Alleles,
pubmed-meshheading:18675632-Antigens, CD18,
pubmed-meshheading:18675632-Case-Control Studies,
pubmed-meshheading:18675632-Child, Preschool,
pubmed-meshheading:18675632-DNA Mutational Analysis,
pubmed-meshheading:18675632-Enterocolitis,
pubmed-meshheading:18675632-Female,
pubmed-meshheading:18675632-Gene Expression Regulation, Developmental,
pubmed-meshheading:18675632-Gene Frequency,
pubmed-meshheading:18675632-Genetic Predisposition to Disease,
pubmed-meshheading:18675632-Genetic Testing,
pubmed-meshheading:18675632-Genetic Variation,
pubmed-meshheading:18675632-Hirschsprung Disease,
pubmed-meshheading:18675632-Humans,
pubmed-meshheading:18675632-Infant,
pubmed-meshheading:18675632-Infant, Newborn,
pubmed-meshheading:18675632-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:18675632-Male,
pubmed-meshheading:18675632-Mutation,
pubmed-meshheading:18675632-Polymerase Chain Reaction,
pubmed-meshheading:18675632-Polymorphism, Genetic,
pubmed-meshheading:18675632-Probability,
pubmed-meshheading:18675632-Reference Values,
pubmed-meshheading:18675632-Sensitivity and Specificity
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pubmed:year |
2008
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pubmed:articleTitle |
The ITGB2 immunomodulatory gene (CD18), enterocolitis, and Hirschsprung's disease.
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pubmed:affiliation |
Division of Paediatric Surgery, Faculty of Health Sciences, University of Stellenbosch, PO Box 19063, 7505 Tygerberg, South Africa. swm@sun.ac.za <swm@sun.ac.za>
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pubmed:publicationType |
Journal Article,
Comparative Study
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