rdf:type |
|
lifeskim:mentions |
umls-concept:C0003451,
umls-concept:C0071649,
umls-concept:C0220781,
umls-concept:C0331292,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0871161,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C1708235,
umls-concept:C1883254
|
pubmed:issue |
16
|
pubmed:dateCreated |
2008-8-11
|
pubmed:abstractText |
An efficient synthesis of the acid part of salvianolic acid E 2 is described. Compound 2 was obtained from vanillin in 10 steps and 21% overall yield. During the synthesis of 2 an unexpected 5-oxo-4b,9b-dihydroindano[1,2-b]benzofuran rac-12 was isolated. Both compounds together with the acid part of salvianolic acid D were active as HIV-1 integrase inhibitors at the submicromolar level. But they did not inhibit the replication of the virus on MT-4 cells.
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pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Benzaldehydes,
http://linkedlifedata.com/resource/pubmed/chemical/Bromides,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Integrase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Integrase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Phenols,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Polyphenols,
http://linkedlifedata.com/resource/pubmed/chemical/vanillin
|
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
1464-3405
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pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:day |
15
|
pubmed:volume |
18
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
4736-40
|
pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18674899-Antiviral Agents,
pubmed-meshheading:18674899-Benzaldehydes,
pubmed-meshheading:18674899-Bromides,
pubmed-meshheading:18674899-Cell Line,
pubmed-meshheading:18674899-Chemistry, Pharmaceutical,
pubmed-meshheading:18674899-Drug Design,
pubmed-meshheading:18674899-Enzyme Inhibitors,
pubmed-meshheading:18674899-Flavonoids,
pubmed-meshheading:18674899-HIV Integrase Inhibitors,
pubmed-meshheading:18674899-Humans,
pubmed-meshheading:18674899-Inhibitory Concentration 50,
pubmed-meshheading:18674899-Integrase Inhibitors,
pubmed-meshheading:18674899-Models, Chemical,
pubmed-meshheading:18674899-Phenols,
pubmed-meshheading:18674899-Plant Extracts,
pubmed-meshheading:18674899-Polyphenols,
pubmed-meshheading:18674899-Salvia
|
pubmed:year |
2008
|
pubmed:articleTitle |
Synthesis and antiviral properties of some polyphenols related to Salvia genus.
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pubmed:affiliation |
Laboratoire de Chimie Organique et Macromoléculaire, UMR CNRS 8009, USTL, 59655 Villeneuve d'Ascq, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|