| pubmed-article:18673389 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18673389 | lifeskim:mentions | umls-concept:C0317608 | lld:lifeskim |
| pubmed-article:18673389 | lifeskim:mentions | umls-concept:C1135183 | lld:lifeskim |
| pubmed-article:18673389 | lifeskim:mentions | umls-concept:C0227309 | lld:lifeskim |
| pubmed-article:18673389 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:18673389 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18673389 | pubmed:dateCreated | 2008-12-3 | lld:pubmed |
| pubmed-article:18673389 | pubmed:abstractText | Host-microorganism interactions in the intestinal tract are complex, and little is known about specific nonpathogenic microbial factors triggering host responses in the gut. In this study, mannose-specific interactions of Lactobacillus plantarum 299v with jejunal epithelium were investigated using an in situ pig Small Intestinal Segment Perfusion model. The effects of L. plantarum 299v wild-type strain were compared with those of two corresponding mutant strains either lacking the gene encoding for the mannose-specific adhesin (msa) or sortase (srtA; responsible for anchoring of cell surface proteins like Msa to the cell wall). A slight enrichment of the wild-type strain associated with the intestinal surface could be observed after 8 h of perfusion when a mixture of wild-type and msa-mutant strain had been applied. In contrast to the mutant strains, the L. plantarum wild-type strain tended to induce a decrease in jejunal net fluid absorption compared with control conditions. Furthermore, after 8 h of perfusion expression of the host gene encoding pancreatitis-associated protein, a protein with proposed bactericidal properties, was found to be upregulated by the wild-type strain only. These observations suggest a role of Msa in the induction of host responses in the pig intestine. | lld:pubmed |
| pubmed-article:18673389 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18673389 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18673389 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18673389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18673389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18673389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18673389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18673389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18673389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18673389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18673389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18673389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18673389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18673389 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18673389 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18673389 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:18673389 | pubmed:issn | 0928-8244 | lld:pubmed |
| pubmed-article:18673389 | pubmed:author | pubmed-author:KleerebezemMi... | lld:pubmed |
| pubmed-article:18673389 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:18673389 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:18673389 | pubmed:author | pubmed-author:SmitsMari AMA | lld:pubmed |
| pubmed-article:18673389 | pubmed:author | pubmed-author:NiewoldTheo... | lld:pubmed |
| pubmed-article:18673389 | pubmed:author | pubmed-author:SnelJohannesJ | lld:pubmed |
| pubmed-article:18673389 | pubmed:author | pubmed-author:HulstMarcel... | lld:pubmed |
| pubmed-article:18673389 | pubmed:author | pubmed-author:GrossGabriele... | lld:pubmed |
| pubmed-article:18673389 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18673389 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:18673389 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18673389 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18673389 | pubmed:pagination | 215-23 | lld:pubmed |
| pubmed-article:18673389 | pubmed:dateRevised | 2010-2-8 | lld:pubmed |
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| pubmed-article:18673389 | pubmed:meshHeading | pubmed-meshheading:18673389... | lld:pubmed |
| pubmed-article:18673389 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18673389 | pubmed:articleTitle | Mannose-specific interaction of Lactobacillus plantarum with porcine jejunal epithelium. | lld:pubmed |
| pubmed-article:18673389 | pubmed:affiliation | Animal Breeding and Genomics Centre, Animal Sciences Group of Wageningen UR, Lelystad, The Netherlands. | lld:pubmed |
| pubmed-article:18673389 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18673389 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18673389 | lld:pubmed |
