Linked Life Data

18673285

Source:http://linkedlifedata.com/resource/pubmed/id/18673285

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-8-4
pubmed:abstractText
After a short introduction with some examples of cytotoxic ribonucleases, the importance of natural or artificial dimerization (oligomerization) as a way for a ribonuclease to acquire novel functional properties has been pointed out. In particular, the role of the three dimensional domain swapping mechanism in bovine pancreatic ribonuclease A oligomerization, as well as its impact for the acquisition of novel biological functions (among which a remarkable antitumor action) by the enzyme protein in oligomeric form have been discussed. Finally, the structural and functional features that could explain why oligomeric ribonuclease A becomes able to display a cytotoxic activity, and the possible use and limits of the three dimensional domain-swapped oligomers of ribonuclease A as anticancer therapeutic agents have been described and discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1873-4316
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
200-9
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
A novel biological actions acquired by ribonuclease through oligomerization.
pubmed:affiliation
Dipartimento di Scienze Morfologico-Biomediche, Sezione di Chimica Biologica, Istituti Biologici, Strada Le Grazie 8, I-37134 Verona, Italy. massimo.libonati@univr.it
pubmed:publicationType
Journal Article, Review