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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-9-16
pubmed:abstractText
Apolipoprotein D (apoD) is a lipoprotein-associated glycoprotein that is increased in the hippocampus and cerebrospinal fluid of patients with Alzheimer's disease (AD), which implies that apoD might be involved in the pathogenesis of AD. We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing techniques to screen all exons (1-5) and the flanking exon-intron boundaries of the apoD gene (APOD). Thirty subjects [15 sporadic AD (SAD) patients and 15 controls] were randomly selected and tested for APOD variations by direct sequencing. Two APOD polymorphisms (rs5952T/C and rs1568566C/T) were detected. We further investigated APOD polymorphisms in 256 SAD patients and 294 healthy subjects from a North Chinese population to investigate whether they affect the risk of SAD. Logistic analysis revealed that both rs5952 C and rs1568566 T alleles increase the risk of SAD [rs5952, adjusted odds ratio (OR) 1.817, 95% confidence interval (CI) 1.237-2.669, P = 0.002; rs1568566, adjusted OR 1.563, 95% CI 1.060-2.306, P = 0.024). The rs5952T-rs1568566C haplotype showed lower risk of SAD (OR 0.421, 95% CI 0.305-0.583, P = 0.000). Case-control analysis revealed that the rs5952T-rs1568566C haplotype could serve as a novel defendant factor against SAD. APOD polymorphisms might play an important role in modifying SAD risk in some way.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
1233
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
196-202
pubmed:meshHeading
pubmed-meshheading:18671953-Aged, pubmed-meshheading:18671953-Aged, 80 and over, pubmed-meshheading:18671953-Alzheimer Disease, pubmed-meshheading:18671953-Apolipoproteins D, pubmed-meshheading:18671953-Case-Control Studies, pubmed-meshheading:18671953-Chi-Square Distribution, pubmed-meshheading:18671953-China, pubmed-meshheading:18671953-Chromosomes, Human, Pair 3, pubmed-meshheading:18671953-Female, pubmed-meshheading:18671953-Gene Frequency, pubmed-meshheading:18671953-Genetic Predisposition to Disease, pubmed-meshheading:18671953-Humans, pubmed-meshheading:18671953-Linkage Disequilibrium, pubmed-meshheading:18671953-Logistic Models, pubmed-meshheading:18671953-Male, pubmed-meshheading:18671953-Polymorphism, Single Nucleotide, pubmed-meshheading:18671953-Reference Values, pubmed-meshheading:18671953-Sex Factors
pubmed:year
2008
pubmed:articleTitle
Association between polymorphisms in the apolipoprotein D gene and sporadic Alzheimer's disease.
pubmed:affiliation
Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing 100053, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't