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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-8-14
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pubmed:abstractText |
A number of prostaglandins (PGs) sensitize dorsal root ganglion (DRG) neurons and contribute to inflammatory hyperalgesia by signaling through specific G protein-coupled receptors (GPCRs). One mechanism whereby PGs sensitize these neurons is through modulation of "thermoTRPs," a subset of ion channels activated by temperature belonging to the Transient Receptor Potential ion channel superfamily. Acrid, electrophilic chemicals including cinnamaldehyde (CA) and allyl isothiocyanate (AITC), derivatives of cinnamon and mustard oil respectively, activate thermoTRP member TRPA1 via direct modification of channel cysteine residues.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-10371510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-10781090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-11786541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-12196566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-12654248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-14712238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-15046718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-15639643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-15843607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-15916949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-16198309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-16564016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-16630838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-17164327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-17237762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-17567811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-17686976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-17942735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-18000030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-18322093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-8521498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-8993549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-9422508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18671867-9422509
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1744-8069
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
30
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18671867-Animals,
pubmed-meshheading:18671867-CHO Cells,
pubmed-meshheading:18671867-Calcium Channels,
pubmed-meshheading:18671867-Cells, Cultured,
pubmed-meshheading:18671867-Cricetinae,
pubmed-meshheading:18671867-Cricetulus,
pubmed-meshheading:18671867-Ganglia, Spinal,
pubmed-meshheading:18671867-HeLa Cells,
pubmed-meshheading:18671867-Humans,
pubmed-meshheading:18671867-Male,
pubmed-meshheading:18671867-Mice,
pubmed-meshheading:18671867-Mice, Inbred C57BL,
pubmed-meshheading:18671867-Mice, Knockout,
pubmed-meshheading:18671867-Nerve Tissue Proteins,
pubmed-meshheading:18671867-Nociceptors,
pubmed-meshheading:18671867-Pain Measurement,
pubmed-meshheading:18671867-Prostaglandin D2,
pubmed-meshheading:18671867-Rats,
pubmed-meshheading:18671867-Signal Transduction,
pubmed-meshheading:18671867-Skin Physiological Phenomena,
pubmed-meshheading:18671867-Transient Receptor Potential Channels
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pubmed:year |
2008
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pubmed:articleTitle |
Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1.
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pubmed:affiliation |
Washington University Pain Center, Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63130, USA. orengol@morpheus.wustl.edu
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pubmed:publicationType |
Journal Article,
Comparative Study
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