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pubmed-article:18670622pubmed:abstractTextMaternal enterovirus infections during pregnancy may increase the risk of offspring developing type 1 diabetes during childhood. The aim of this study was to investigate whether gestational enterovirus infections increase the offspring's risk of type 1 diabetes later in life. Serum samples from 30 mothers without diabetes whose offspring developed type 1 diabetes between 15 and 25 years of age were analyzed for enterovirus-specific immunoglobulin M (IgM) antibodies and enterovirus genome (RNA), and compared to a control group. Among the index mothers, 9/30 (30%) were enterovirus IgM-positive, and none was positive for enterovirus RNA. In the control group, 14/90 (16%) were enterovirus IgM-positive, and 4/90 (4%) were positive for enterovirus RNA (n.s.). Boys of enterovirus IgM-positive mothers had approximately 5 times greater risk of developing diabetes (OR 4.63; 95% CI 1.22-17.6), as compared to boys of IgM-negative mothers (P < .025). These results suggest that gestational enterovirus infections may be related to the risk of offspring developing type 1 diabetes in adolescence and young adulthood.lld:pubmed
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pubmed-article:18670622pubmed:articleTitleMaternal enterovirus infection during pregnancy as a risk factor in offspring diagnosed with type 1 diabetes between 15 and 30 years of age.lld:pubmed
pubmed-article:18670622pubmed:affiliationDepartment of Clinical Sciences, Pediatric Unit, Lund University Hospital, Lund University, 221 85 Lund, Sweden. maria.elfving@med.lu.selld:pubmed
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pubmed-article:18670622pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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