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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-8-1
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pubmed:abstractText |
Maternal enterovirus infections during pregnancy may increase the risk of offspring developing type 1 diabetes during childhood. The aim of this study was to investigate whether gestational enterovirus infections increase the offspring's risk of type 1 diabetes later in life. Serum samples from 30 mothers without diabetes whose offspring developed type 1 diabetes between 15 and 25 years of age were analyzed for enterovirus-specific immunoglobulin M (IgM) antibodies and enterovirus genome (RNA), and compared to a control group. Among the index mothers, 9/30 (30%) were enterovirus IgM-positive, and none was positive for enterovirus RNA. In the control group, 14/90 (16%) were enterovirus IgM-positive, and 4/90 (4%) were positive for enterovirus RNA (n.s.). Boys of enterovirus IgM-positive mothers had approximately 5 times greater risk of developing diabetes (OR 4.63; 95% CI 1.22-17.6), as compared to boys of IgM-negative mothers (P < .025). These results suggest that gestational enterovirus infections may be related to the risk of offspring developing type 1 diabetes in adolescence and young adulthood.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18670622-10330298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18670622-10333962,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18670622-9700636
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
1687-5303
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
2008
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
271958
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18670622-Adolescent,
pubmed-meshheading:18670622-Adult,
pubmed-meshheading:18670622-Age of Onset,
pubmed-meshheading:18670622-Child, Preschool,
pubmed-meshheading:18670622-Diabetes Mellitus, Type 1,
pubmed-meshheading:18670622-Enterovirus,
pubmed-meshheading:18670622-Enterovirus Infections,
pubmed-meshheading:18670622-Female,
pubmed-meshheading:18670622-Fetal Blood,
pubmed-meshheading:18670622-Genetic Predisposition to Disease,
pubmed-meshheading:18670622-Humans,
pubmed-meshheading:18670622-Infant, Newborn,
pubmed-meshheading:18670622-Male,
pubmed-meshheading:18670622-Polymerase Chain Reaction,
pubmed-meshheading:18670622-Pregnancy,
pubmed-meshheading:18670622-Pregnancy Complications,
pubmed-meshheading:18670622-Risk Factors,
pubmed-meshheading:18670622-Sweden
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pubmed:year |
2008
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pubmed:articleTitle |
Maternal enterovirus infection during pregnancy as a risk factor in offspring diagnosed with type 1 diabetes between 15 and 30 years of age.
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pubmed:affiliation |
Department of Clinical Sciences, Pediatric Unit, Lund University Hospital, Lund University, 221 85 Lund, Sweden. maria.elfving@med.lu.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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