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rdf:type |
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lifeskim:mentions |
umls-concept:C0007131,
umls-concept:C0034802,
umls-concept:C0242356,
umls-concept:C0544886,
umls-concept:C0871261,
umls-concept:C0936012,
umls-concept:C1268567,
umls-concept:C1519724,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
8
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pubmed:dateCreated |
2008-8-1
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pubmed:abstractText |
After the discovery of somatic mutations in the tyrosine kinase domain (exons 18-24) of the epidermal growth factor receptor (EGFR) correlating with responses of non-small cell lung cancer (NSCLC) to the tyrosine kinase inhibitors (TKIs) gefitinib and erlotinib, there has been increasing interest in utilizing this molecular marker for treatment selection. We aimed to analytically catalogue the mutational spectrum of somatic mutations in EGFR and format a database allowing correlation of specific mutations with clinico-pathologic factors and response to TKIs.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1556-1380
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
832-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18670300-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:18670300-Databases, Factual,
pubmed-meshheading:18670300-Humans,
pubmed-meshheading:18670300-Lung Neoplasms,
pubmed-meshheading:18670300-Mutation,
pubmed-meshheading:18670300-Prognosis,
pubmed-meshheading:18670300-Protein Kinase Inhibitors,
pubmed-meshheading:18670300-Quinazolines,
pubmed-meshheading:18670300-Receptor, Epidermal Growth Factor,
pubmed-meshheading:18670300-Treatment Outcome
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pubmed:year |
2008
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pubmed:articleTitle |
Somatic mutations of the tyrosine kinase domain of epidermal growth factor receptor and tyrosine kinase inhibitor response to TKIs in non-small cell lung cancer: an analytical database.
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pubmed:affiliation |
Department of Molecular Biology, Metropolitan Hospital, N. Faliro, 18547, Athens, Greece. smbhsam@hotmail.com
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pubmed:publicationType |
Journal Article
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