Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5889
pubmed:dateCreated
2008-8-1
pubmed:databankReference
pubmed:abstractText
MyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). MyD88 deficiency in mice leads to susceptibility to a broad range of pathogens in experimental settings of infection. We describe a distinct situation in a natural setting of human infection. Nine children with autosomal recessive MyD88 deficiency suffered from life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease. However, these patients were otherwise healthy, with normal resistance to other microbes. Their clinical status improved with age, but not due to any cellular leakiness in MyD88 deficiency. The MyD88-dependent TLRs and IL-1Rs are therefore essential for protective immunity to a small number of pyogenic bacteria, but redundant for host defense to most natural infections.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-10435584, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-10839543, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-11067888, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-11861602, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-11923871, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-12637671, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-12872135, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-14982987, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-15004134, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-15375173, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-15618166, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-15849357, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-16207247, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-16286015, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-16413925, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-16551253, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-16585605, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-16936244, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-16973841, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-17034585, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-17185603, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-17352533, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-17673650, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-17872438, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-17893200, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-17952041, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-18039950, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-4315461, http://linkedlifedata.com/resource/pubmed/commentcorrection/18669862-9697844
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1095-9203
pubmed:author
pubmed-author:AbelLaurentL, pubmed-author:AlsinaLaiaL, pubmed-author:AntónJordiJ, pubmed-author:ArósteguiJuan IgnacioJI, pubmed-author:BanchereauJacquesJ, pubmed-author:CamciogluYildizY, pubmed-author:CasanovaJean-LaurentJL, pubmed-author:ChangHuey-HsuanHH, pubmed-author:ChapelHelenH, pubmed-author:ChaussabelDamienD, pubmed-author:ChrabiehMayaM, pubmed-author:FortunyClaudiaC, pubmed-author:GartyBen-ZionBZ, pubmed-author:GhandilPegahP, pubmed-author:GuedesMargaridaM, pubmed-author:Herrero-MataMaría JoséMJ, pubmed-author:IssekutzAndrewA, pubmed-author:JanniereLucileL, pubmed-author:JinZhongboZ, pubmed-author:JuanManelM, pubmed-author:KuCheng-LungCL, pubmed-author:LiXiaoxiaX, pubmed-author:MaródiLászlóL, pubmed-author:MustaphaImen BenIB, pubmed-author:PanklaRungnapaR, pubmed-author:PascalMarionaM, pubmed-author:PicardCapucineC, pubmed-author:PuelAnneA, pubmed-author:RodrigoCarlosC, pubmed-author:Rodriguez-GallegoCarlosC, pubmed-author:RoseYoannY, pubmed-author:Ruiz-OrtizEstibalizE, pubmed-author:SirventNicolasN, pubmed-author:VasconcelosJúliaJ, pubmed-author:VitorArtur BonitoAB, pubmed-author:XiaoHuiH, pubmed-author:YagüeJordiJ, pubmed-author:von BernuthHorstH
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
321
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
691-6
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
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