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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5893
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pubmed:dateCreated |
2008-8-29
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pubmed:abstractText |
The generation of pluripotent stem cells from an individual patient would enable the large-scale production of the cell types affected by that patient's disease. These cells could in turn be used for disease modeling, drug discovery, and eventually autologous cell replacement therapies. Although recent studies have demonstrated the reprogramming of human fibroblasts to a pluripotent state, it remains unclear whether these induced pluripotent stem (iPS) cells can be produced directly from elderly patients with chronic disease. We have generated iPS cells from an 82-year-old woman diagnosed with a familial form of amyotrophic lateral sclerosis (ALS). These patient-specific iPS cells possess properties of embryonic stem cells and were successfully directed to differentiate into motor neurons, the cell type destroyed in ALS.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1095-9203
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pubmed:author |
pubmed-author:ChungWendyW,
pubmed-author:CroftGist FGF,
pubmed-author:DimosJohn TJT,
pubmed-author:EgganKevinK,
pubmed-author:GolandRobinR,
pubmed-author:HendersonChristopher ECE,
pubmed-author:LeibelRudyR,
pubmed-author:MitsumotoHiroshiH,
pubmed-author:NiakanKathy KKK,
pubmed-author:RodolfaKit TKT,
pubmed-author:SaphierGenevieveG,
pubmed-author:WeisenthalLaurin MLM,
pubmed-author:WichterleHynekH
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pubmed:issnType |
Electronic
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pubmed:day |
29
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pubmed:volume |
321
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1218-21
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pubmed:meshHeading |
pubmed-meshheading:18669821-Aged, 80 and over,
pubmed-meshheading:18669821-Amyotrophic Lateral Sclerosis,
pubmed-meshheading:18669821-Cell Differentiation,
pubmed-meshheading:18669821-Cell Line,
pubmed-meshheading:18669821-Embryonic Stem Cells,
pubmed-meshheading:18669821-Female,
pubmed-meshheading:18669821-Fibroblasts,
pubmed-meshheading:18669821-Gene Expression,
pubmed-meshheading:18669821-Humans,
pubmed-meshheading:18669821-Motor Neurons,
pubmed-meshheading:18669821-Neuroglia,
pubmed-meshheading:18669821-Nuclear Reprogramming,
pubmed-meshheading:18669821-Pluripotent Stem Cells,
pubmed-meshheading:18669821-Retroviridae,
pubmed-meshheading:18669821-Spinal Cord,
pubmed-meshheading:18669821-Superoxide Dismutase,
pubmed-meshheading:18669821-Transcription Factors,
pubmed-meshheading:18669821-Transduction, Genetic
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pubmed:year |
2008
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pubmed:articleTitle |
Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons.
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pubmed:affiliation |
Harvard Stem Cell Institute, Stowers Medical Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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